全体研究人员 学术带头人

周国瑛

职称:

教授

研究方向:

单纯疱疹病毒与宿主细胞的对抗

单纯疱疹病毒的恶性神经胶质瘤基因治疗

单纯疱疹病毒的潜伏与复发的分子机理研究

科研项目:

1、肺癌靶向治疗

2、HSV-1的潜伏与激活的分子机制

3、实体瘤的病毒免疫治疗

4、细胞因子风暴的病毒介入抑制

代表性学术论文:

1.、Du T#, Zhou G#, Roizman B. 2011. HSV-1 gene expression from reactivated ganglia is disordered and concurrent with suppression of latency-associated transcript and miRNAs. Proc Natl Acad Sci U S A. 108(46):18820-4. (Co-first author) (IF:9.8 Cited by 35). (#Co-first author)

2、Du T#, ZhouG#, Roizman B. 2012. Induction of apoptosis accelerates reactivation of latent HSV-1 in ganglionic organ cultures and replication in cell cultures. ProcNatlAcadSci U S A. 109(36):14616-21. (#Co-first author)

3、Zhou G., Du T. and Roizman B. 2013. HSV carrying wild-type REST establishes latency but reactivates only if the synthesis of REST is suppressed. ProcNatlAcadSci U S A. 110(6):E498-506。

4、Du T#, ZhouG#, Roizman B. 2013. Modulation of reactivation of latent herpes simplex virus 1 in ganglionic organ cultures by p300/CBP and STAT3. ProcNatlAcadSci U S A. 110 (28): E2621-8. (#Co-first author)

5、Du T, Han Z, Zhou G*, Roizman B*. 2014. Patterns of accumulation of miRNAs encoded by herpes simplex virus during productive infection, latency, and on reactivation. Proc. Nat. Acad. Sci. (USA)112(1):E49-55. (*Co-Corresponding Author)

获奖及个人荣誉:

1、国务院特殊津贴(1988年获得)

联系方式:

Email: gzhou1149@163.com