代表性成果
1、Macrophage-to-myofibroblast transdifferentiation contributes to pulmonary fibrosis via the MERTK-SPP1-SRC-TKS5 signaling axis (2026). Advanced Science. e75620.
2、Impaired ciliogenesis in small airway epithelial cells involves in the development of idiopathic pulmonary fibrosis (2025). BBA Molecular Basis of Disease. 1871(8):167992.
3、Overexpression of STX11 alleviates pulmonary fibrosis by inhibiting fibroblast activation via the PI3K/AKT/mTOR pathway (2024). Signal Transduction and Targeted Therapy. 9(1):306.
4、Induction of CTGF accounts for the inability of glucocorticoid suppression on lung fibrosis (2022). Clinical and Translational Medicine. 12(5):e867.
5、Dicoumarol is an effective post-exposure prophylactic for SARS-CoV-2 omicron infection in human respiratory epithelium (2023). Signal Transduction and Targeted Therapy. 8(1):242.
6、Elevated expression of macrophage MERTK exhibits profibrotic effects and results in defective regulation of efferocytosis function in pulmonary fibrosis (2023). Respiratory Research. 24(1):118.
7、Multi-omics evaluation of SARS-CoV-2 infected mouse lungs reveals dynamics of host responses (2022). iScience. 25(3):103967.
8、LncRNA GAS5 suppresses TGF-β1-induced transformation of pulmonary pericytes into myofibroblasts by recruiting KDM5B and promoting H3K4me2/3 demethylation of the PDGFRα/β promoter (2023). Molecular Medicine. 29(1):32.
9、IdentIfication and validation of autophagy-related gene expression for predicting prognosis in patients with idiopathic pulmonary fibrosis (2022). Frontiers in Immunology.13:997138.
10、Role of ADAM and ADAMTS proteases in pathological tissue remodeling (2023). Cell Death Discovery. 9(1):447.
11、Irreversibility of pulmonary fibrosis (2022). Aging and Disease. 13 (1): 73-86.
12、Virus infection induced pulmonary fibrosis (2021). Journal of Translational Medicine. 19(1): 496.
13、Role of interleukins in the pathogenesis of pulmonary fibrosis (2021). Cell Death Discovery. 7(1): 52.
14、Regulation of macrophage activation by lactylation in lung disease (2024). Frontiers in Immunology.15:1427739.
15、2025 Annual review of basic and translational research advances in pulmonary fibrosis:a narrative review (2026). Journal of Thoracic Disease. doi: 10.21037/jtd-2026- 0767.
获奖及个人荣誉
主要学术任职
1、中国研究型医院学会呼吸病学专业委员会委员
2、中国生理学会呼吸生理专业委员会委员
3、中国罕见病联盟呼吸病学分会常务委员
4、中国药理学会呼吸药理专业委员会常务委员
5、广东省呼吸与健康学会呼吸罕见病与间质性肺病专委会主任委员
6、广东省劳模和工匠人才创新工作室(肺纤维化创新研究工作室)负责人
7、教育部学位中心评审专家
8、Science Translational Medicine等国际SCI期刊同行评议专家
个人荣誉
1、国家高层次人才
2、国家高层次留学人才
3、广东省杰出青年医学人才
4、广东省劳模和工匠人才创新工作室(肺纤维化创新研究工作室)领衔人
5、广东省珠江人才计划本土创新科研团队核心成员
6、广州市医学重点人才
7、广州市优秀专家
8、广州榜样·抗疫劳动者
9、创新工作室十大创新成果榜首
10、广州医科大学好能手
11、广州医科大学三八红旗手标兵
12、广州医科大学附属第一医院优秀研究生导师