全体研究人员 学组负责人
名字:唐潇潇
职务:学组负责人
职称:教授
研究方向:间质性肺病/肺纤维化
联系方式:tangxiaoxiao@gird.cn
研究工作

肺损伤与肺纤维化等呼吸疾病发病机制与防治策略的基础与转化研究


科研项目

1、国家高层次人才项目,主持,2017-2020

2、国家自然科学基金面上项目 (3项,先后主持)

3、广东省珠江人才计划本土创新科研团队项目,核心成员,2018-2023

4、广东省科技厅新冠肺炎重大应急攻关项目,课题负责人,2020-2021


代表性成果

1、Macrophage-to-myofibroblast transdifferentiation contributes to pulmonary fibrosis via the MERTK-SPP1-SRC-TKS5 signaling axis (2026). Advanced Science. e75620.

2、Impaired ciliogenesis in small airway epithelial cells involves in the development of idiopathic pulmonary fibrosis (2025). BBA Molecular Basis of Disease. 1871(8):167992.

3、Overexpression of STX11 alleviates pulmonary fibrosis by inhibiting fibroblast activation via the PI3K/AKT/mTOR pathway (2024). Signal Transduction and Targeted Therapy. 9(1):306.

4、Induction of CTGF accounts for the inability of glucocorticoid suppression on lung fibrosis (2022). Clinical and Translational Medicine. 12(5):e867.

5、Dicoumarol is an effective post-exposure prophylactic for SARS-CoV-2 omicron infection in human respiratory epithelium (2023). Signal Transduction and Targeted Therapy. 8(1):242.

6、Elevated expression of macrophage MERTK exhibits profibrotic effects and results in defective regulation of efferocytosis function in pulmonary fibrosis (2023). Respiratory Research. 24(1):118.

7、Multi-omics evaluation of SARS-CoV-2 infected mouse lungs reveals dynamics of host responses (2022). iScience. 25(3):103967.

8、LncRNA GAS5 suppresses TGF-β1-induced transformation of pulmonary pericytes into myofibroblasts by recruiting KDM5B and promoting H3K4me2/3 demethylation of the PDGFRα/β promoter (2023). Molecular Medicine. 29(1):32.

9、IdentIfication and validation of autophagy-related gene expression for predicting prognosis in patients with idiopathic pulmonary fibrosis (2022). Frontiers in Immunology.13:997138.

10、Role of ADAM and ADAMTS proteases in pathological tissue remodeling (2023). Cell Death Discovery. 9(1):447.

11、Irreversibility of pulmonary fibrosis (2022). Aging and Disease. 13 (1): 73-86.

12、Virus infection induced pulmonary fibrosis (2021). Journal of Translational Medicine. 19(1): 496.

13、Role of interleukins in the pathogenesis of pulmonary fibrosis (2021). Cell Death Discovery. 7(1): 52.

14、Regulation of macrophage activation by lactylation in lung disease (2024). Frontiers in Immunology.15:1427739.

15、2025 Annual review of basic and translational research advances in pulmonary fibrosis:a narrative review (2026). Journal of Thoracic Disease. doi: 10.21037/jtd-2026- 0767.


获奖及个人荣誉

主要学术任职

1、中国研究型医院学会呼吸病学专业委员会委员

2、中国生理学会呼吸生理专业委员会委员

3、中国罕见病联盟呼吸病学分会常务委员

4、中国药理学会呼吸药理专业委员会常务委员

5、广东省呼吸与健康学会呼吸罕见病与间质性肺病专委会主任委员

6、广东省劳模和工匠人才创新工作室(肺纤维化创新研究工作室)负责人

7、教育部学位中心评审专家

8、Science Translational Medicine等国际SCI期刊同行评议专家


个人荣誉

1、国家高层次人才

2、国家高层次留学人才

3、广东省杰出青年医学人才

4、广东省劳模和工匠人才创新工作室(肺纤维化创新研究工作室)领衔人

5、广东省珠江人才计划本土创新科研团队核心成员

6、广州市医学重点人才

7、广州市优秀专家

8、广州榜样·抗疫劳动者

9、创新工作室十大创新成果榜首

10、广州医科大学好能手

11、广州医科大学三八红旗手标兵

12、广州医科大学附属第一医院优秀研究生导师