1、呼吸系统病毒进化变异及宿主相互作用机制研究

2、呼吸系统病毒感染天然和获得性免疫答研究

3、呼吸系统传染病疫苗和抗体药物研发

1、“政府间国际科技创新合作”重点专项，2026-2028

2、国家自然科学基金 重大项目，2025-2029

3、国家杰出青年科学基金项目，2021-2025

4、国家自然科学基金国际(地区)合作与交流项目（组织间合作研究—NSFC-RGC（内地-香港）），2019-2022

5、国家自然科学基金组织器官区域免疫特性与疾病重大研究计划，2019-2021

6、国家重点研发计划《生物安全关键技术研发专项》，2018-2021

1、Ran W#, Yang J#, Yu S#, Hu Q#, He Y#, Wang S, Wei C, Sun J, Zhu A, Li F, Zhang L, Li P, Hu H, Pan R, Yu Y, Yuan Y, Sun L, Wang Y, Zhang Z, Chen Z, Liu D, Yan Q, Wang D, Yu K, Wang Y, Zhuo J, Zhuang Z, Tao H, Zeng Q, Zhou K, Chen F, Tang W, Zhou Y, Bai R, Xu Y, Li N, Dai J, Zhao H, Park JE, Wang T, Ding Q*, Perlman S*, Zhao J*, Mao Y*, Wang S*, Zhao J*. Interferon-stimulated gene GALNT2 restricts respiratory virus infections. Nat Microbiol. 2026 Jan;11(1):256-270.

2、Zhu A#, Chen Z#, Yan Q#, Jiang M#, Liu X#, Li Z#, Li N#, Tang C#, Jian W#, He J, Chen L, Cheng J, Chen C, Tang T, Xu Z, Hu Q, Li F, Wang Y, Sun J, Zhuang Z, Wen L, Zhuo J, Liu D, Zhang Y, Huang X, Li S, Zeng Q, Chen F, Zhou L, Liu D, Zhong C, Chen Y, Li S, Liang K, Zhong N, Zhang X, Chen J, Chen X*, Xu Y*, Zhong N*, Zhao J*, Zhao J*. Robust mucosal SARS-CoV-2-specific T cells effectively combat COVID-19 and establish polyfunctional resident memory in patient lungs. Nat Immunol. 2025 Mar;26(3):459-472.

3、Wang Y#, Yan A#, Song D#, Duan M#, Dong C, Chen J, Jiang Z, Gao Y, Rao M, Feng J, Zhang Z, Qi R, Ma X, Liu H, Yu B, Wang Q, Zong M, Jiao J, Xing P, Pan R, Li D, Xiao J, Sun J, Li Y, Zhang L, Shen Z, Sun B, Zhao Y, Zhang L, Dai J, Zhao J, Wang L*, Dou C*, Liu Z*, Zhao J*. Identification of a highly conserved neutralizing epitope within the RBD region of diverse SARS-CoV-2 variants. Nat Commun. 2024 Jan 29;15(1):842.

4、Liu D#, Chen C#, Chen D#, Zhu A#, Li F#, Zhuang Z#, Mok CKP#, Dai J#, Li X#, Jin Y#, Chen Z, Sun J, Wang Y, Li Y, Zhang Y, Wen L, Zhang Z, Zhuo J, Wang J, Ran W, Wang D, Zhang S, Tang Y, Li S, Lai X, Wei P, Yuan J, Chen F, Huang S, Sun F, Qian Z, Tan W, Zhao J, Peiris M*, Zhao J*. Mouse models susceptible to HCoV-229E and HCoV-NL63 and cross protection from challenge with SARS-CoV-2. Proc Natl Acad Sci U S A. 2023 Jan 24;120(4):e2202820120.

5、Zhuang Z#, Lai X#, Sun J#, Chen Z#, Zhang Z#, Dai J#, Liu D#, Li Y#, Li F#, Wang Y, Zhu A, Wang J, Yang W, Huang J, Li X, Hu L, Wen L, Zhuo J, Zhang Y, Chen D, Li S, Huang S, Shi Y, Zheng K, Zhong N, Zhao J*, Zhou D*, Zhao J*. Mapping and role of T cell response in SARS-CoV-2-infected mice. J Exp Med. 2021 Apr 5;218(4):e20202187.

6、Mok CKP#, Zhu A#, Zhao J#, Lau EHY, Wang J, Chen Z, Zhuang Z, Wang Y, Alshukairi AN, Baharoon SA, Wang W, Tan W, Liang W, Oladipo JO, Perera RAPM, Kuranga SA, Peiris M*, Zhao J*. T-cell responses to MERS coronavirus infection in people with occupational exposure to dromedary camels in Nigeria: an observational cohort study. Lancet Infect Dis. 2021 Mar;21(3):385-395.

7、Sun J#, Zhuang Z#, Zheng J#, Li K#, Wong RL#, Liu D#, Huang J#, He J#, Zhu A#, Zhao J#, Li X#, Xi Y#, Chen R, Alshukairi AN, Chen Z, Zhang Z, Chen C, Huang X, Li F, Lai X, Chen D, Wen L, Zhuo J, Zhang Y, Wang Y, Huang S, Dai J, Shi Y, Zheng K, Leidinger MR, Chen J, Li Y, Zhong N, Meyerholz DK, McCray PB Jr*, Perlman S*, Zhao J*. Generation of a Broadly Useful Model for COVID-19 Pathogenesis, Vaccination, and Treatment. Cell. 2020 Aug 6;182(3):734-743.e5.

8、Wang Y#, Zhang L#, Sang L#, Ye F#, Ruan S#, Zhong B#, Song T#, Alshukairi AN#, Chen R#, Zhang Z, Gan M, Zhu A, Huang Y, Luo L, Mok CK, Al Gethamy MM, Tan H, Li Z, Huang X, Li F, Sun J, Zhang Y, Wen L, Li Y, Chen Z, Zhuang Z, Zhuo J, Chen C, Kuang L, Wang J, Lv H, Jiang Y, Li M, Lin Y, Deng Y, Tang L, Liang J, Huang J, Perlman S, Zhong N, Zhao J*, Malik Peiris JS*, Li Y*, Zhao J*. Kinetics of viral load and antibody response in relation to COVID-19 severity. J Clin Invest. 2020 Oct 1;130(10):5235-5244.

9、Zhao J#, Alshukairi AN#, *, Baharoon SA, Ahmed WA, Bokhari AA, Nehdi AM, Layqah LA, Alghamdi MG, Al Gethamy MM, Dada AM, Khalid I, Boujelal M, Al Johani SM, Vogel L, Subbarao K, Mangalam A, Wu C, Ten Eyck P, Perlman S*, Zhao J*. Recovery from the Middle East respiratory syndrome is associated with antibody and T-cell responses. Sci Immunol. 2017 Aug 4;2(14). pii: eaan5393.

10、Zhao J#, *, Zhao J#, Mangalam AK, Channappanavar R, Fett C, Meyerholz DK, Agnihothram S, Baric RS, David CS, Perlman S*. Airway Memory CD4 T Cells Orchestrate Protective Immunity against Emerging Human Respiratory Coronaviruses. Immunity. 2016 Jun 21;44(6):1379-91.

11、Zhao J#, Li K, Wohlford-Lenane C, Agnihothram SS, Fett C, Zhao J, Gale MJ Jr, Baric RS, Enjuanes L, Gallagher T, McCray PB Jr, Perlman S*. Rapid generation of a mouse model for Middle East Respiratory Syndrome. Proc Natl Acad Sci U S A. 2014 Apr; 111:4970-4975. (Cited by Nature, Science and Faculty 1000).

12、Zhao J#, Zhao J, Legge K, Perlman S*. Age-related increases in PGD2 expression impair respiratory DC migration, resulting in diminished T cell responses upon respiratory virus infection in mice. J Clin Invest. 2011 Dec; 121:4921-4930. (Commentary by T. Kim and T. Braciale, Cited by Nature/SCIBX and Faculty 1000)

1、《全省学校优秀教学成果奖》（高等教育-本科类），一等奖，排名第一，2025

2、《2023年中华预防医学会科学技术奖》，二等奖，排名第二，2024

3、《全球前2%顶尖科学家榜单》，爱思唯尔和斯坦福大学，2021, 2022, 2024-2025

4、《高被引科学家》，科睿唯安，2021-2025

5、《2022年中华医学科技奖》，三等奖，排名第二，2023

6、《广东省科学技术进步奖特等奖》，排名第四，广东省科技厅，2021

7、《高层次人才特岗教授》，新型冠状病毒感染的传染病防治特设岗位，教育部，2021

8、《国家杰出青年科学基金项目》，国家自然科学基金委员会，2021

9、《享受政府特殊津贴人选》，人力资源与社会保障部，2020

10、《全国创新争先奖》，广州医科大学新冠肺炎疫情防控研究南山团队，排名第三，人力资源社会保障部、中国科协、科技部、国务院国资委，2020

11、《广东特支计划》，科技创新领军人才，广东省科技厅，2019

12、《广东省医学领军人才》，广东省卫生健康委，2019