全体研究人员
名字:袁斌
职务:学术带头人
职称:教授
研究方向: 重大呼吸系统感染与黏膜免疫
联系方式:18394514301@163.com
研究工作

1、呼吸道病原体的致病机制研究及靶向药物筛选;

2、呼吸道病毒的新型疫苗设计与免疫增效。

科研项目

1、国家自然科学基金青年基金项目,32400119,宿主I型拓扑异构酶(hTOP1)调控埃博拉病毒聚合酶活性的分子机制研究,2025/01-2027/12,在研,主持;

2、教育部-广东省科学厅联动项目,中央高校青年教师科研创新能力支持项目,2025/12-2028/12,在研,主持

3、广州实验室-广州医科大学联合项目,靶向呼吸道合胞/偏肺病毒融合蛋白F的广谱抗体和环肽药物研究,2025/10-2028/10,在研,主持;

代表性成果

1. Peng Q#, Yuan B#, Cheng J#, Wang M, Gao S, Bai S, Zhao X, Qi J*, Gao GF*, Shi Y*. Molecular mechanism of de novo replication by the Ebola virus polymerase. Nature. 2023 Oct;622(7983):603-610. doi: 10.1038/s41586-023-06608-1.

2. Yuan B#, Peng Q#, Cheng J, Wang M, Zhong J, Qi J, Gao GF*, Shi Y*. Structure of the Ebola virus polymerase complex. Nature. 2022 Oct;610 (7931):394-401. doi: 10.1038 /s41586-022-05271-2.

3. Sun C#, Zhang L#, Yi H#, Wan S#, Zhu A#, Yuan B#, Yan Q, Peng X, Yu C, Zhang X, Fu K, Zeng J, Shi Y, Huang L, Wang Y, Zhao J, Li B. Isolation and genomic characterization of Chikungunya virus during the 2025 outbreak in Foshan, China. Emerg Microbes Infect. 2025 Dec;14(1):2595790. doi: 10.1080/22221751.2025.2595790.

4. Peng Q#, Peng R#, Yuan B#, Wang M, Zhao J, Fu L, Qi J, Shi Y*. Structural Basis of SARS-CoV-2 Polymerase Inhibition by Favipiravir.The Innovation.2021 Feb 28;2(1):100080. doi: 10.1016/j.xinn.2021.100080.

5. Peng Q#, Peng R#, Yuan B#, Zhao J#, Wang M, Wang X, Wang Q, Sun Y, Fan Z, Qi J, Gao GF*, Shi Y*. Structural and Biochemical Characterization of the nsp12-nsp7-nsp8 Core Polymerase Complex from SARS-CoV-2. Cell Reports. 2020 Jun 16;31(11):107774. doi: 10.1016/j.celrep.2020.107774.

6. Liu Y#, Yuan B#, Peng L, Zhao J, Cheng B, Huang Y, Zheng X, Zhou Y, Xiang S, Zhu L*, Wu Y*. Single-particle analysis of urea amidolyase reveals its molecular mechanism.Protein Science. 2020 May;29(5):1242-1249. doi: 10.1002/pro.3847.