代表性成果
1、Shen Q M†, Deng E Z†, Luo L, Zhang J N, Yang Q F, Su D, Fan X Y*. High-throughput single-cell DNA methylation and chromatin accessibility co-profiling with SpliCOOL-seq[J]. Clinical and Translational Medicine, 2026, 16: e70584.
2、Huang D†, Zheng Y†, Deng E Z†, Ji X L, Zhang Y C, Sun H, Chen Y S, Yao Y X, Zhou Y, Zhang M X, Zhou Z, Chen Y H, Su D, Fan X Y*, Chen X W*, Pei R J*. Chromatin remodeler BAF maintains HBV cccDNA transcriptional competence and represents a therapeutic target[J]. Nucleic Acids Research, 2026, 54(4): gkag07.
3、Liu N†, Wu J Y†, Deng E Z†, Zhong J L†, Wei B†, Cai T T†, Duan X H, Fu S, Osei-Hwedieh D O, Huang K Z, Zhuang P L, Sha O, Lin H Y, Li Q X, Lu P C, Miao J H, Yamada T, Chen Y S, Lv X B, Zhu Y Y, Zhang L Z, Cai L, Du H W, Baca S C, Ferrone S, Wang X*, Xu F*, Fan X Y*, Fan S*. Immunotherapy and senolytics in head and neck squamous cell carcinoma: phase 2 trial results[J]. Nature Medicine, 2025, 9: 3047-3061.
4、Deng E Z†, Shen Q M†, Zhang J N, Fang Y W, Chang L, Luo G Z, Fan X Y*. Systematic evaluation of single-cell RNA-seq analyses performance based on long-read sequencing[J]. Journal of Advanced Research, 2025, 71: 141-153.
5、Li W†, Su D†, Li X N†, Lu K, Huang Q P, Zheng J J, Luo X P, Chen G*, Fan X Y*. Identification of the core regulatory program driving NEUROD1-induced neuronal reprogramming[J]. Cell Reports, 2025, 4: 1-16.
6、Xu X Y†, Wang J†, Hu K H, Luo Y, Su D, Huang Q P, Fan X T*, Fan X Y*. Single-cell Isoform Sequencing Reveals Transcriptional Dysregulation in ASD Mouse Cortex Development[J]. Genomics, Proteomics & Bioinformatics, 2025: 1-33.
7、Wang C Y†, Shi Z X†, Huang Q P, Liu R, Su D, Chang L, Xiao C L, Fan X Y*. Single-cell analysis of isoform switching and transposable element expression during preimplantation embryonic development[J]. PLoS Biology, 2024, 2: 1-22.
8、Chang L†, Deng E Z†, Wang J†, Zhou W†, Ao J, Liu R, Su D, Fan X Y*. Single-cell third-generation sequencing-based multi-omics uncovers gene expression changes governed by ecDNA and structural variants[J]. Clinical and Translational Medicine, 2023, 8: 1-22.
9、Fan X Y†, Lu P†, Wang H W†, Bian S H†, Wu X L†, Zhang Y, Liu Y, Fu D Q, Wen L, Hao J H*, Tang F C*. Integrated single-cell multiomics analysis reveals novel candidate markers for prognosis in human pancreatic ductal adenocarcinoma[J]. Cell Discovery, 2022, 1: 1-13.
10、Fan X Y†, Yang C†, Li W†, Bai X Z, Zhou X, Xie H L, Wen L, Tang F C. SMOOTH-seq: single-cell genome sequencing of human cells on a thirdgeneration sequencing platform[J]. Genome Biology, 2021, 1: 1-19.
11、Ren X W†, Wen W†, Fan X Y†, Hou W H†, Su B†, Cai P F†, Li J S†, Liu Y†, Tang F†, Zhang F†, Yang Y†, He J P†, Ma W J†, He J J†, Wang P P†, Cao Q Q, Chen F J, Chen Y Q, Cheng X L, Deng G H, Deng X L, Ding W Y, Feng Y M, Gan R, Guo C, Guo W Q, He S, Jiang C, Liang J R, Li Y M, Lin J, Ling Y, Liu H F, Liu J W, Liu N P, Liu S Q, Luo M, Ma Q, Song Q B, Sun W A, et al., Zhang Z M*. COVID-19 immune features revealed by a large-scale single-cell transcriptome atlas[J]. Cell, 2021, 7: 1895-1913.
董晓楠
