课题组致力于整合干细胞模型、小鼠遗传模型与功能基因组学技术，结合基因编辑与多组学生物信息学分析，系统解析代谢性疾病与慢性呼吸系统疾病的遗传与表观遗传调控机制，揭示疾病相关的代谢重编程与跨器官信号网络，并推动精准干预策略与靶向治疗手段的开发。

研究方向包括：

1、代谢性疾病与慢性呼吸系统疾病中遗传变异驱动的表观调控机制及其功能解析

2、慢性呼吸系统疾病中的代谢重编程及其在疾病发生发展中的作用

3、跨器官通讯网络（如肝–肺轴）在机体稳态维持与疾病进展中的调控机制

4、药物响应异质性的分子基础解析及精准治疗策略的开发

1、PPARg不同异构体在糖尿病药物反应中的作用与分子机理研究 国家自然科学基金委员会 面上

2、面向肺癌精准医疗的多模态肿瘤类器官芯片开发与智能决策系统构建 国家自然科学基金委员会高技术研究发展中心 重点研发

3、慢阻肺早期演进的代谢调控机制与干预策略研究 广州国家实验室 实验室专项

4、呼吸动态微生理系统的开发及其在肺损伤精准医疗中的应用研究 广州国家实验室 实验室专项

1、Biying Zhu#, Na He#, Yang Xiao#,*, Bin Chen#, Chen Li#, Ravi Mandla, Yifan Liu, Jiayu Zhang, Xiao Chang, Fulong Yu, Marijana Vujkovic, Julie A. Lynch, Kyong-Mi Chang, VA Million Veteran Program, Bogdan Pasaniuc, Daniel J. Rader, Mitchell A. Lazar* & Wenxiang Hu*. Integrative analyses elucidate transcriptional regulatory functions of risk alleles for metabolic liver disease. Nature genetics. 2026.

2、Jie Yao#, Su Fang#, Miao Lei#, Zexian Ou, Chuanfei Zeng, Wanli Peng, Na He, Lian Yang, Bingpeng Guo, Mingmeng Fang, Cuihua Wang, Jie Lv, Shuang Wu, Wei Kevin Zhang, Huimin Huang, Yang Peng, Wei Rao, Zhili Rong, Penghui Yang, Chaoqun Wang, Qian Han* & Wenxiang Hu*. Dietary intake and BCAA metabolism regulate pulmonary fibrosis through KDM4A-mediated epigenetic remodeling in male mice.Nature Communications. 2026.

3、Xianju Wang#, Chen Li#, Zongzheng Gui#, Yubei Jin#, Sijian Xia, Han Zhao, Yifei Wang, Minxian Dai, Suhua He, Yihang Zhong, Xiaozhi Lin, Qiang Xu, Wei Peng, Hongtu Zhao, Jinsai Shang, Haoyue Zhang & Wenxiang Hu*. EBF2 condensates enable adipose thermogenesis through ZFP423 sequestration and epigenetic remodeling.Nature Communications. 2026.

4、Cuihua Wang, Na He, Shixiang Wang, Miao Lei, Jie Yao, Li Lin, Xue Ding, Jiaman Lin, Yixin Chen, Qiaoyun Long, Hannah Xiaoyan Hui, Liwei Xie, Yun-Shen Chan, Nan Cao, Shanshan Gu* & Wenxiang Hu*. Inhibition of adipocyte RUNX1/2 enhances adipose tissue thermogenesis through distinct mechanisms. Nature Communications. 2026.

5、Wenxiang Hu*, Mitchell Lazar*. Modelling metabolic diseases and drug response using stem cells and organoids. Nature Reviews Endocrinology. 2022.

6、Wenxiang Hu#*, Chunjie Jiang#, Mindy Kim, Wenjian Yang, Kun Zhu, Dongyin Guan, Wenjian Lv, Yang Xiao, Jessica R Wilson, Daniel J Rader, Ching-Hon Pui, Mary V. Relling, Mitchell A. Lazar*. Individual-specific functional epigenomics reveals genetic determinants of adverse metabolic effects of glucocorticoids. Cell Metabolism, 2021.

7、Wenxiang Hu#, Chunjie Jiang#, Dongyin Guan, Pieterjan Dierickx, Rong Zhang, Arden Moscati, Girish N. Nadkarni, David J. Steger, Ruth J.F. Loos, Cheng Hu, Weiping Jia, Raymond E. Soccio, and Mitchell A. Lazar*. Patient adipose stem cell-derived adipocytes reveal genetic variation that predicts anti-diabetic drug response. Cell Stem Cell, 2019.

8、Wenxiang Hu*#, Chunjie Jiang#, Mindy Kim, Yang Xiao, Hannah J. Richter, Dongyin Guan, Kun Zhu,Brianna M Krusen, Arielle N. Roberts, Jessica Miller, David J. Steger, Mitchell A. Lazar*. Isoform-specific functions of PPARg in gene regulation and metabolism. Genes & Development, 2022.

9、Cuihua Wang#, Xianju Wang#, WenxiangHu*. Molecular and cellular regulation of thermogenic fat. Frontiers in Endocrinology. 2023.

10、Li Lin#, Miao lei#, Jiaman Lin#, Wenxiang Hu*. Advances and applications in liver organoid technology. SCIENTIA SINICA Vitae. 2021.

1、2024 广州市领军人才

2、2022 国家重大人才项目入选者（青年）

3、2022 广东省重大人才工程青年拔尖人才

4、2022 广州市开发区精英人才