郑国沛-全体研究人员-人才队伍-呼吸疾病全国重点实验室

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人才队伍

全体研究人员 • 学术带头人

人才队伍全体研究人员

郑国沛

职务：

广州医科大学肿瘤研究所副所长

职称：

研究员

研究方向：

肺癌

研究工作：

肿瘤发生、转移及治疗耐受机制研究，肿瘤新诊治靶点的筛选鉴定及转化应用研究。

科研项目：

1、国家自然科学基金面上项目，HOXD8募集SIRT6重塑超级增强子景观以抑制乳腺癌细胞恶性进展和免疫逃逸的机制研究，项目编号：82372761，2024/01-2027/12，49万；

2、国家自然科学基金面上项目，JAM3/ADGRE5互作介导的细胞间通讯在血管内皮细胞诱导乳腺癌干细胞向周细胞分化中的作用及机制，项目编号：82173189，2022/01-2025/12，55万；

3、国家自然科学基金面上项目，肿瘤细胞缺氧诱发的浸润性B淋巴细胞代谢重编程在舌癌生长中的作用及机制，项目编号：81872197，2019/01-2022/12，58万；

4、国家自然科学基金面上项目，TGFβ2促发内质网应激在巨噬细胞参与乳腺癌耐药和转移中的作用及机制，项目编号：81672616，2017/01-2020/12，57万；

5、国家自然科学基金青年项目，EZH2介导的FGF2对话miRNAs在诱导并维持乳腺癌细胞上皮间质转化及化疗耐受中的作用，项目编号：81402196，2015/01-2017/12，23万；

6、广东省自然科学基金杰出青年基金项目，TGFβ2-mTORC1-XBP1诱发内质网应激介导的耐药细胞与巨噬细胞交互作用促进乳腺癌进展，项目编号：2016A030306003， 2016/06-2020/06，100万。

代表性学术论文：

1、Liyun Luo, Zhijie Zhang, Ni Qiu, Li Ling, Xiaoting Jia, Ying Song, Hongsheng Li, Jiansheng Li, Hui Lyu, Hao Liu, Zhimin He, Bolin Liu, Guopei Zheng*. Disruption of FOXO3a-miRNA feedback inhibition of IGF2/IGF-1R/IRS1 signaling results in Herceptin resistance in HER2-positive breast cancer. Nature Communications, 2021, 12(1):2699.

2、Nan Li, Guohua Yang, Liyun Luo, Li Ling, Xiaorong Wang, Lejuan Shi, Junsong Lan, Xiaoting Jia, Qiong Zhang, Ze Long, Jinbao Liu, Weimin Hu, Zhimin He, Haiying Liu, Wanqing Liu, Guopei Zheng*. LncRNA THAP9-AS1 promotes pancreatic ductal adenocarcinoma growth and leads to a poor clinical outcome via sponging miR-484 and interacting with YAP. Clinical Cancer Research, 2020, 26(7):1736-1748.

3、Hao Liu, Hui Lyu, Guanmin Jiang, Danyang Chen, Sanbao Ruan, Shuang Liu, Lukun Zhou, Minqiang Yang, Shanshan Zeng, Zhimin He, Hongsheng Wang, Hongsheng Li, Guopei Zheng*, Bolin Liu*. ALKBH5-Mediated m6A Demethylation of GLUT4 mRNA Promotes Glycolysis and Resistance to HER2-Targeted Therapy in Breast Cancer. Cancer Research, 2022, 82(21):3974-3986.

4、Hao Liu, Ying Song, Huishi Qiu, Yanzhen Liu, Kai Luo, Yanmei Yi, Guanmin Jiang, Minying Lu, Zhijie Zhang, Jiang Yin, Shanshan Zeng, Xiangzhou Chen, Min Deng, Xiaoting Jia, Yixue Gu, Danyang Chen, Guopei Zheng*, Zhimin He*. Downregulation of FOXO3a by DNMT1 promotes breast cancer stem cell properties and tumorigenesis. Cell Death & Differentiation, 2020, 27(3):966-983.

5、Zhijie Zhang, Ni Qiu, Jiang Yin, Jianlei Zhang, Hao Liu, Wei Guo, Meijun Liu, Ting Liu, Danyang Chen, Kai Luo, Hongsheng Li, Zhimin He, Jinbao Liu, Guopei Zheng*. SRGN crosstalks with YAP to maintain chemoresistance and stemness in breast cancer cells by modulating HDAC2 expression. Theranostics, 2020, 10(10): 4290-4307.

6、Guodong Tang, Liyun Luo, Jianlei Zhang, Dongfeng Zhai, Danqing Huang, Jiang Yin, Qin Zhou, Qiong Zhang, Guopei Zheng*. lncRNA LINC01057 promotes mesenchymal differentiation by activating NF-κB signaling in glioblastoma. Cancer Letters, 2021, 498:152-164.

7、Xiaoting Jia, Ge Wang, Lihong Wu, Hao Pan, Li Ling, Jianlei Zhang, Qingquan Wen, Jie Cui, Zhimin He, Bin Qi, Shuxu Zhang, Liyun Luo, Guopei Zheng*. XBP1-elicited environment by chemotherapy potentiates repopulation of tongue cancer cells by enhancing miR-22/lncRNA/KAT6B-dependent NF-κB signaling. Clinical and Translational Medicine, 2023, 13(1):e1166.

8、Liyun Luo, Hailin Tang, Li Ling, Nan Li, Xiaoting Jia, Zhijie Zhang, Xiaorong Wang, Lejuan Shi, Jiang Yin, Ni Qiu, Hao Liu, Ying Song, Kai Luo, Hongsheng Li, Zhimin He, Guopei Zheng*, Xiaoming Xie*. LINC01638 lncRNA activates MTDH-Twist1 signaling by preventing SPOP-mediated c-Myc degradation in triple-negative breast cancer. Oncogene, 2018, 37(47):6166-6179.

9、Guopei Zheng, Zhijie Zhang, Hao Liu, Yan Xiong, Liyun Luo, Xiaoting Jia, Cong Peng, Qiong Zhang, Nan Li, Yixue Gu, Minying Lu, Ying Song, Hao Pan, Jinbao Liu, Wanqing Liu, Zhimin He. HSP27-mediated Extracellular and Intracellular Signaling Pathways Synergistically Confer Chemo-Resistance in Squamous Cell Carcinoma of Tongue. Clinical Cancer Research, 2018, 24(5): 1163-1175.