
郑国沛
职务:
广州医科大学肿瘤研究所副所长
职称:
研究员
研究方向:
恶性肿瘤发生、转移及治疗耐受机制研究。
科研项目:
1、肿瘤细胞缺氧诱发的浸润性B淋巴细胞代谢重编程在舌癌生长中的作用及机制,项目编号:81872197,国家自然科学基金面上项目,2019/01-2022/12,58万;
2、TGFβ2促发内质网应激在巨噬细胞参与乳腺癌耐药和转移中的作用及机制,项目编号:81672616,国家自然科学基金面上项目,2017/01-2020/12,57万;
3、EZH2介导的FGF2对话miRNAs在诱导并维持乳腺癌细胞上皮间质转化及化疗耐受中的作用,项目编号:81402196,国家自然科学基金青年项目,2015/01-2017/12,23万;
4、TGFβ2-mTORC1-XBP1诱发内质网应激介导的耐药细胞与巨噬细胞交互作用促进乳腺癌进展,项目编号:2016A030306003,广东省自然科学基金杰出青年基金项目,2016/06-2020/06,100万;
5. 自分泌和旁分泌信号在诱导和维持乳腺癌细胞上皮-间质转化以介导耐药和转移中的作用及机制,项目编号:2017A030313867,广东省自然科学基金一般项目,2017/05-2020/05,10万;
6. 放化疗诱发的内质网应激在头颈部恶性肿瘤生长和治疗反应中的作用及机制,项目编号:201710010100,广州市珠江科技新星项目,017/05-2020/05,30万。
代表性学术论文:
1、Zhijie Zhang, Ni Qiu, Jiang Yin, Jianlei Zhang, Hao Liu, Wei Guo, Meijun Liu, Ting Liu, Danyang Chen, Kai Luo, Hongsheng Li, Zhimin He, Jinbao Liu, Guopei Zheng. SRGN crosstalks with YAP to maintain chemoresistance and stemness in breast cancer cells by modulating HDAC2 expression. Theranostics, 2020, 10(10): 4290-4307.
2、Nan Li, Guohua Yang, Liyun Luo, Li Ling, Xiaorong Wang, Lejuan Shi, Junsong Lan, Xiaoting Jia, Qiong Zhang, Ze Long, Jinbao Liu, Weimin Hu, Zhimin He, Haiying Liu, Wanqing Liu, Guopei Zheng. LncRNA THAP9-AS1 promotes pancreatic ductal adenocarcinoma growth and leads to a poor clinical outcome via sponging miR-484 and interacting with YAP. Clin Cancer Res, 2020; 26(7):1736-1748.
3、Hao Liu, Ying Song, Huishi Qiu, Yanzhen Liu, Kai Luo, Yanmei Yi, Guanmin Jiang, Minying Lu, Zhijie Zhang, Jiang Yin, Shanshan Zeng, Xiangzhou Chen, Min Deng, Xiaoting Jia, Yixue Gu, Danyang Chen, Guopei Zheng#, Zhimin He#. Downregulation of FOXO3a by DNMT1 promotes breast cancer stem cell properties and tumorigenesis. Cell Death & Differentiation, 2020, 27(3):966-983.
4、Xiaoting Jia, Lejuan Shi, Xiaorong Wang, Liyun Luo, Li Ling, Jiang Yin, Ying Song, Zhijie Zhang , Ni Qiu, Hao Liu, Min Deng, Zhimin He, Hongsheng Li, Guopei Zheng. KLF5 regulated lncRNA RP1 promotes the growth and metastasis of breast cancer via repressing p27kip1 translation. Cell Death & Disease, 2019, 10(5):373.
5、Liyun Luo, Hailin Tang, Li Ling, Nan Li, Xiaoting Jia, Zhijie Zhang, Xiaorong Wang, Lejuan Shi, Jiang Yin, Ni Qiu, Hao Liu, Ying Song, Kai Luo, Hongsheng Li, Zhimin He, Guopei Zheng#, Xiaoming Xie#. LINC01638 lncRNA activates MTDH-Twist1 signaling by preventing SPOP-mediated c-Myc degradation in triple-negative breast cancer. Oncogene, 2018; 37(47):6166-6179.
6、Guopei Zheng, Zhijie Zhang, Hao Liu, Yan Xiong, Liyun Luo, Xiaoting Jia, Cong Peng, Qiong Zhang, Nan Li, Yixue Gu, Minying Lu, Ying Song, Hao Pan, Jinbao Liu, Wanqing Liu, Zhimin He. HSP27-mediated Extracellular and Intracellular Signaling Pathways Synergistically Confer Chemo-Resistance in Squamous Cell Carcinoma of Tongue. Clin Cancer Res, 2018, 24(5): 1163-1175.
7、Zheng G, Peng C, Jia X, Gu Y, Zhang Z, Deng Y, Wang C, Li N, Yin J, Liu X, Lu M, Tang H, He Z. ZEB1 transcriptionally regulated carbonic anhydrase 9 mediates the chemoresistance of tongue cancer via maintaining intracellular pH. Mol Cancer, 2015; 14:84.
获奖及个人荣誉:
1、“广东特支计划”科技创新青年拔尖人才;
2、广东省自然科学基金杰出青年基金项目获得者;
3、广州市珠江科技新星项目获得者;
4、广州市高层次卫生人才医学重点人才。
联系方式:
Email:zhengguopei@126.com