职称：

研究员

研究工作：

1、肿瘤转录异常关键靶标的动态结构-致癌功能关系研究

2、靶向致癌表观遗传调节蛋白和谱系特异性致癌转录因子的创新药物发现研究

3、现有表观遗传药物在恶性肿瘤和遗传性疾病治疗中的精准应用

研究方向：

药物化学生物学、肿瘤表观遗传学

科研项目：

1、肺巨噬细胞在流感病毒感染后继发革兰氏阴性菌感染的作用与机制研究，主持，国家级，2015-01--2017-12

2、磷脂酶sPLA2G2E缺失导致动脉粥样硬化新机制的研究，主持，国家级，2015-01--2018-12

3、应对新发/突发呼吸系统病毒传染性疾病，主持，市地级，2014-01--2016-12

4、广州市协同创新重大专项子专题“呼吸道新发突发及重大传染病综合防诊治”，主持，市地级，2014-01--2017-12

5、H7N9猴血清制备和猴抗体研发，参与，专项级，2013-07--2016-12

代表性学术论文：

1、Kong X#, Chen J#, Xie W#, Brown S, Cai Y, Wu K, Fan D, Nie Y, Yegnasubramanian S, Tiedemann R, Tao Y, Yen R, Topper MJ, Easwaran H, Rothbart SB*, Xia L*, Baylin SB*, Defining UHRF1 Domains That Support Maintenance of Human Colon Cancer DNA Methylation and Oncogenic Properties, Cancer Cell. 2019;35(4):633-648

2、Kong X#, Liu J#, Li L, Yue L, Zhang L, Jiang H, Xie X*, Luo C*, Functional interplay between the RK motif and linker segment dictates Oct4-DNA recognition, Nucleic Acids Res. 2015;43(9):4381-92

3、Kong X#, Chen L#, Jiao L, Jiang X, Lian F, Lu J, Zhu K, Du D, Liu J, Ding H, Zhang N, Shen J, Zheng M, Chen K, Liu X, Jiang H, Luo C*. Astemizole arrests the proliferation of cancer cells by disrupting the EZH2-EED interaction of polycomb repressive complex 2, J Med Chem. 2014;57(22):9512-21

4、Ye F#, Kong X#, Zhang H, Liu Y, Shao Z, Jin J, Cai Y, Zhang R, Li L, Zhang YW, Liu YC, Zhang C, Xie W, Yu K, Ding H, Zhao K, Chen S, Jiang H*, Baylin SB*, Luo C*. Biochemical Studies and Molecular Dynamic Simulations Reveal the Molecular Basis of Conformational Changes in DNA Methyltransferase-1, ACS Chem Biol. 2018;13(3):772-781

5、Zhu M#, Du D#, Hu J, Li L, Liu J, Ding H, Kong X*, Jiang H, Chen K, Luo C*, Development of a high-throughput fluorescence polarization assay for the discovery of EZH2-EED interaction inhibitors, Acta Pharmacol Sin. 2018;39(2):302-310

6、Kong X#, Qin J#, Li Z#, Vultur A, Tong L, Feng E, Rajan G, Liu S, Lu J, Liang Z, Zheng M, Zhu W, Jiang H, Herlyn M, Liu H, Marmorstein R*, Luo C*., Development of a novel class of B-RafV600E-selective inhibitors through virtual screening and hierarchical hit optimization, Organ Biomol Chem, 2012;10:7402-17

7、Lu J#, Kong X#, Luo C*, Li KK*. Application of Epigenome-Modifying Small Molecules in Induced Pluripotent Stem Cells, Med Res Rev, 2012, May 11, DOI:10.1002/med.21265

8、Kong X#, Ouyang S#, Liang Z, Lu J, Chen L, Shen B, Li D, Zheng M, Li KK*, Luo C*, Jiang H., Catalytic Mechanism Investigation of Lysine-Specific Demethylase 1 (LSD1): A computational study, PLoS ONE, 2011; 6(9): e25444

9、Chen L#, Kong X#, Liang Z, Ye F, Yu K, Dai W, Wu D*, Luo C*, Jiang H, Theoretical study of the mechanism of proton transfer in the esterase EstB from Burkholderia gladioli, J Phys Chem B, 2011;115 (44), 13019-13025

获奖及个人荣誉：

1、2019年 AACR-Get Your Rear in Gear Philadelphia Scholar in Training Award

2、2015年 上海市研究生优秀学位论文

联系方式：

Email: kong_xiangqian@gibh.ac.cn