导师介绍
姓名 | 汤海洋 | 性别 | 男 |
民族 | 汉族 | 导师层次 | 博士生导师 |
职称 | 教授 | 导师类型 | 学术型 |
学历 | 博士研究生 | 学位 | 博士 |
行政职务 | 无 | 邮箱 | tanghy2008@yahoo.com |
招生方向 | 临床医学-呼吸内科-肺血管疾病 |
汤海洋,博士,教授。2007 年博士毕业于中国科学院北京动物研究所,2008 年出国后分别在美国伊利诺伊大学药理系和医学系作为博士后进行呼吸疾病相关的基础研究工作。2014 年在亚利桑那大学任职研究助理教授,专注于肺动脉高压发生发展机理研究。2017 年回国受聘于广州医科大学,在呼吸疾病国家重点实验室任职教授、博士生导师,主要研究方向为肺血管疾病机制研究。目前主持国家级省部级项目 10 余项。在 Am J Respir Crit Care Med, Hypertension, Circ Res, JACC Basic Transl Sci, Redox Biol 等杂志发表 SCI 论文 80 余篇,累计影响因子达 500 点,他引次数 2500 多次。
1、肺动脉高压发生发展的细胞分子机制;
2、信号转导在心血管疾病以及右心衰竭发生发展中的调控作用;
3、肺动脉高压药物研发及治疗作用研究。
1、Zhang L, Li Y, Wang J, Hong C, Lu W, Qu Y, Black SM, Chen Q, Zhou T, Jin W, Duan E, Tang H*, Zhang Y*. RNA Modification Signature of Peripheral Blood as a Potential Diagnostic Marker for Pulmonary Hypertension. Hypertension. 2022 Jan 11.
2、Wang H, Sun X, Lu Q, Zemskov EA, Yegambaram M, Wu X, Wang T, Tang H*, Black SM*. The mitochondrial redistribution of eNOS is involved in lipopolysaccharide induced inflammasome activation during acute lung injury. Redox Biol. 2021 Jan 26;41:101878.
3、Sun H#, Zhang F#, Xu Y, Sun S, Pan Y, Wang H, Du Q, Gu C, Black S, Han Y*, Tang H*. Salusin-β promotes vascular calcification via NAD(P)H/ROS mediated Klotho downregulation. Antioxid Redox Signal. 2019 Oct 3.
4、Tang H#, Wu K#, Wang J#, Vinjamuri S, Gu Y, Song S, Wang Z, Zhang Q, Balistrieri A, Ayon RJ, Rischard F, Vanderpool R, Chen J, Zhou G, Desai AA, Black SM, Garcia JGN, Yuan JX, Makino A*. Pathogenic Role of mTORC1 and mTORC2 in Pulmonary Hypertension. JACC Basic Transl Sci. 2018 Dec;3(6):744-762.
5、Tang H#, Babicheva A#, McDermott KM, Gu Y, Ayon RJ, Song S, Wang Z, Gupta A, Zhou T, Sun X, Dash S, Wang Z, Balistrieri A, Zheng Q, Cordery AG, Desai AA, Rischard F, Khalpey Z, Wang J, Black SM, Garcia JGN, Makino A, Yuan JX*. Endothelial HIF-2α contributes to severe pulmonary hypertension due to endothelial-to-mesenchymal transition. Am J Physiol Lung Cell Mol Physiol. 2018 Feb 1;314(2):L256-L275.
6、Wu K#, Zhang Q#, Wu X#, Lu W#, Tang H#, Liang Z, Gu Y, Song S, Ayon RJ, Wang Z, McDermott KM, Balistrieri A, Wang C, Black SM, Garcia JGN, Makino A, Yuan JX, Wang J*. Chloroquine is a potent pulmonary vasodilator that attenuates hypoxia-induced pulmonary hypertension. Br J Pharmacol. 2017 Nov;174(22):4155-4172.
7、Tang H, Desai AA, Yuan JX. Genetic Insights into Pulmonary Arterial Hypertension. Application of Whole-Exome Sequencing to the Study of Pathogenic Mechanisms. Am J Respir Crit Care Med. 2016 Aug 15;194(4):393-7.
8、Tang H, Fernandez RA, Yuan JX*. miRNA208/Mef2 and TNF-α in right ventricular dysfunction: the transition from hypertrophy to failure. Circ Res. 2015 Jan 2;116(1):6-8.
9、Tang H, Chen J, Fraidenburg DR, Song S, Sysol JR, Drennan AR, Offermanns S, Ye RD, Bonini MG, Minshall RD, Garcia JG, Machado RF, Makino A, Yuan JX*. Deficiency of Akt1, but not Akt2, attenuates the development of pulmonary hypertension. Am J Physiol Lung Cell Mol Physiol. 2015 Jan 15;308(2):L208-20.
10、Chen J#, Tang H#, Sysol JR, Moreno-Vinasco L, Shioura KM, Chen T, Gorshkova I, Wang L, Huang LS, Usatyuk PV, Sammani S, Zhou G, Raj JU, Garcia JG, Berdyshev E, Yuan JX, Natarajan V*, Machado RF*. The sphingosine kinase 1/sphingosine-1-phosphate pathway in pulmonary arterial hypertension. Am J Respir Crit Care Med. 2014 Nov 1;190(9):1032-43.