导师介绍
| 姓名 | 赖宁 | 性别 | 男 |
| 民族 | 汉 | 导师层次 | 博士生导师 |
| 职称 | 副主任医师 | 导师类型 | 学术型、专业型 |
| 学历 | 博士研究生 | 学位 | 博士 |
| 行政职务 | 无 | 邮箱 | congratulation2001@163.com |
| 招生方向 | 肺动脉高压的发病机制及靶向药物治疗 | ||
广东省医学会呼吸病学分会青年委员，广州市高层次人才，广州医科大学与美国约翰霍普金斯大学联合培养博士，美国加州大学圣地亚哥分校博士后，国家重点研发计划“重大慢性非传染性疾病防控研究”重点专项项目骨干，《Experimental Physiology》杂志审稿人，一直从事呼吸内科临床与基础研究工作，近5年来，共主持国家自然科学基金面上项目及青年项目各1项、省级课题1项、市级项目1项、厅局级课题2项、校级课题2项，参与完成国家自然科学基金重点项目等各级别课题4项，并已取得一定成果，共发表各类文章20余篇，其中SCI文章16篇。2020年获广东省科技进步二等奖，2012年获广州市科学技术奖励二等奖。共申请发明专利1项，实用新型专利2项。
主要从事肺动脉高压、肺栓塞及不明原因呼吸困难等肺血管疾病的诊断、药物靶向治疗及发病机制的相关研究。
代表性论文、代表项目、代表性成果奖励等
1、Jain PP#, Lai N#, Xiong M, Chen J, Babicheva A, Zhao T, Parmisano S, Zhao M, Paquin C, Matti M, Powers R, Balistrieri A, Kim NH, Valdez-Jasso D, Thistlethwaite PA, Shyy JY, Wang J, Garcia JGN, Makino A, Yuan JX*. TRPC6, a Therapeutic Target for Pulmonary Hypertension. Am J Physiol Lung Cell Mol Physiol. 2021 Oct 27. doi: 10.1152/ajplung.00159.2021. Online ahead of print.
2、Lai Ning*, Lade Julie, Leggett Kyle, Yun Xin, Baksh Syeda, Chau Eric, Crow Michael T, Sidhaye Venkataramana, Wang Jian, Shimoda Larissa A*. The aquaporin 1 C-terminal tail is required for migration and growth of pulmonary arterial myocytes., American Journal of Respiratory Cell and Molecular Biology, 2014.6, 50(6): 1010~1020
3、Pritesh P. Jain, Tengteng Zhao, Mingmei Xiong, Shanshan Song, Ning Lai, Shane G. Carr, Aleksandra Babicheva, Marisela Rodriguez, Shamin Rahimi, Francesca Balistrieri, Tatum Simonson, Daniela Valdez-Jasso, Patricia A. Thistlethwaite, John Y.-J. Shyy, Jian Wang, Ayako Makino and Jason X.-J. Yuan*. Halofuginone, a Promising Drug for Treatment of Pulmonary Hypertension, Br J Pharmacol. 2021 Mar 10. doi: 10.1111/bph.15442.
4、Xiong M, Jain PP, Chen J, Babicheva A, Zhao T, Alotaibi M, Kim NH, Lai N, Izadi A, Rodriguez M, Li J, Balistrieri A, Balistrieri F, Parmisano S, Sun X, Voldez-Jasso D, Shyy JY, Thistlethwaite PA, Wang J, Makino A, Yuan JX*. Mouse model of experimental pulmonary hypertension: Lung angiogram and right heart catheterization. Pulm Circ. 2021 Sep 8;11(4):20458940211041512.
5、Zhang Q, Tsuji-Hosokawa A, Willson C, Watanabe M, Si R, Lai N, Wang Z, Yuan JX, Wang J, Makino A*. Chloroquine differentially modulates coronary vasodilation in control and diabetic mice. Br J Pharmacol. 2020 Jan;177(2):314-327.
6、Si R, Zhang Q, Tsuji-Hosokawa A, Watanabe M, Willson C, Lai N, Wang J, Dai A, Scott BT, Dillmann WH, Yuan JX, Makino A*. Overexpression of p53 due to excess protein O-GlcNAcylation is associated with coronary microvascular disease in type 2 diabetes. Cardiovasc Res. 2020 May 1;116(6):1186-1198.
7、Jain PP, Hosokawa S, Xiong M, Babicheva A, Zhao T, Rodriguez M, Rahimi S, Pourhashemi K, Balistrieri F, Lai N, Malhotra A, Shyy JY, Valdez-Jasso D, Thistlethwaite PA, Makino A, Yuan JX*. Revisiting the mechanism of hypoxic pulmonary vasoconstriction using isolated perfused/ventilated mouse lung. Pulm Circ. 2020 Nov 25;10(4):2045894020956592.
8、Lai, Ning*; Zeng, Xin; Li, Meichan; Shu, Jiaze, Leydig cell tumor with lung metastasis diagnosed by lung biopsy., Int J Clin Exp Pathol, 2015, 8(10): 12972~12976
9、Lai, Ning*; Lu, Wenju; Wang, Jian(*), Ca(2+) and ion channels in hypoxia-mediated pulmonary hypertension., Int J Clin Exp Pathol, 2015, 8(2): 1081~1092
10、Yun, Xin; Jiang, Haiyang; Lai, Ning; Wang, Jian; Shimoda, Larissa A*, Aquaporin 1-mediated changes in pulmonary arterial smooth muscle cell migration and proliferation involve beta-catenin., Am J Physiol Lung Cell Mol Physiol, 2017.11.1, 313(5): L889~L898
