代表性论文

新型抗流感病毒药物的发现:

1、Jianghong Dong, Mengjie Xiao, Qinge Ma, Guicheng Zhang, Weijie Zhao, Mengjie Kong, Yue Zhang, Luyun Qia, Wenhui Hu*. Design and synthesis of pinane oxime derivatives as novel anti-influenza agents. Bioorganic Chemistry. 2020, 102, 104106-104106.

2、Xin Zhao, Runfeng Li, Yang Zhou, Mengjie Xiao, Chunlong Ma, Zhongjin Yang, Shaogao Zeng, Qiuling Du, Chunguang Yang, Haiming Jiang, Yanmei Hu, Ping Sun, Jianghong Dong, Wei Cui, Kefeng Wang, Jun Wang, Yaoquan Tu, Zifeng Yang, Wenhui Hu*. Discovery of Highly Potent Pinanamine-Based Inhibitors Against Amantadine- and Oseltamivir-resistant Influenza A Viruses. Journal of Medicinal Chemistry. 2018, 61, 5187−5198.

3、Zhengtu Li, Junling Zhao, Hongxia Zhou, Li Li, Yuyang Ding, Jing Li, Beixian Zhou,Haiming Jiang, Nanshan Zhonga, Wenhui Hu*, Zifeng Yang*. Cappariloside A shows antiviral and better anti-inflammatory effects against influenza virus via regulating host IFN signaling, in vitro and vivo. Life Sciences 200 (2018) 115–125.

4、Runfeng Li, Chunguang Yang, Qiuling Du, Xin Zhao, Haiming Jiang, Wenhui Hu*, Zifeng Yang*. Pinanamine Is a Promising Lead Compound against Influenza A Virus: Evidence from in Vitro and in Vivo Efficacy Compared to Amantadine. Biol. Pharm. Bull. 2017, 40, 954–959.

5.、Jianghong Dong, Shengwei Chen, Runfeng Li, Wei Cui, Haiming Jiang, Yixia Ling, Zifeng Yang, Wenhui Hu*. Imidazole-based pinanamine derivatives: Discovery of dual inhibitors of the wild-type and drug-resistant mutant of the influenza A virus. European Journal of Medicinal Chemistry. 2016, 108, 605-615.

6.、Xin Zhao, Yanling Jie, Matthew R. Rosenberg, Junting Wan, Shaogao Zeng, Wei Cui, Yiping Xiao, Zhiyuan Li, Zhengchao Tu, Marco G. Casarotto, Wenhui Hu*. Design and Synthesis of Pinanamine Derivatives as Anti-Influenza A M2 Ion Channel Inhibitors. Antiviral Research. 2012, 96(2):91-99.

7、Xin Zhao, Chufang Li, Shaogao Zeng, Wenhui Hu*. Discovery of highly potent agents against influenza A virus. European Journal of Medicinal Chemistry. 2011, 46 (1):52-57.

8.、Wenhui Hu*, Shaogao Zeng, Chufang Li，Yanling Jie, Zhiyuan Li and Ling Chen. Identification of Hits as Matrix-2 Inhibitors through the Focused Screening of a Small Primary Amine Library. Journal of Medicinal Chemistry. 2010, 53(9): 3831-3834.

抗炎新药的研发：

1.、Hu Yue, Zhongjin Yang, Yitao Ou, Shuli Liang, Wenmin Deng, Hao Chen, Cheng Zhang, Lei Hua, Wenhui Hu*, Ping Sun*. Tanshinones inhibit NLRP3 inflammasome activation by alleviating mitochondrial damage to protect against septic and gouty inflammation. International Immunopharmacology. 2021, 97, 107819.

2.、Cheng Zhang, Hu Yue, Ping Sun, Lei Hua, Shuli Liang, Yitao Ou, Dan Wu, Xinyi Wu, Hao Chen, Ying Hao, Wenhui Hu*, Zhongjin Yang*. Discovery of chalcone analogues as novel NLRP3 inflammasome inhibitors with potent anti-inflammation activities. European Journal of Medicinal Chemistry. 2021, 219, 113417.

3.、Hao Chen, Xiuhui Chen, Ping Sun, Dan Wu, Hu Yue, Jintao Pan, Xinxuan Li, Cheng Zhang, Xinyi Wu, Lei Hua, Wenhui Hu*, Zhongjin Yang*. Discovery of dronedarone and its analogues as NLRP3 inflammasome inhibitors with potent anti-inflammation activity. Bioorganic Medicinal Chemistry letter. 2021, 6, 128160.

4.、Yitao Ou, Ping Sun, NanNan Wu, Hao Chen, Wenhui Hu*, Zhongjin Yang*. Synthesis and biological evaluation of parthenolide derivatives as potential inhibitors of the NLRP3 inflammasome. Bioorganic Medicinal Chemistry letter. 2020, 30 (17), 127399.

5.、Wenmin Deng , Zhongjin Yang, Hu Yue, Yitao Ou, Wenhui Hu*, Ping Sun*. Disulfiram sup presses NLRP3 inflammasome activation to treat peritoneal and gouty inflammation. Free Radical Biology and Medicine, 2020, 152, 8-17.

6.、Yunlong Zhao, Qingxin Zhao, LS Wang, Wen Hui Hu*, Jun Ling Zhao*. Organocatalytic Friedel-Crafts Alkylation /Lactonization Reaction of Naphthols with 3-Trifluoroethylidene Oxindoles: The Asymmetric Synthesis of Dihydrocoumarins. Angewandte Chemie International Edition. 2017, 56, 338 –342.

代表性成果奖励：

广东省科技进步一等奖