黎毅敏
职务:
广州医科大学附属第一医院党委书记
职称:
教授、主任医师
研究方向:
重大呼吸系统感染和肺损伤
研究工作:
长期从事重症医学及呼吸疾病、急性呼吸道传染病诊疗救治工作,在重症感染、ARDS、脓毒症、人工通气、院感控制等方面有较深造诣。
1、急性呼吸窘迫综合征(ARDS)的发病机理和临床救治研究;
2、脓毒血症(Sepsis)的基础与临床研究;
3、人工通气(有创/无创)的呼吸动力学的研究和临床应用;
4、慢性阻塞性肺疾病急性加重(AECOPD)救治。
科研项目:
1、国家自然科学基金面上项目,81970071,脂多糖(LPS)细胞内吞及胞核活化通路:脓毒症相关急性肺损伤的新药物靶点,202001-202312,56万,在研,主持人
2、国家自然科学基金面上项目,82270085,新型冠状病毒肺炎后肺纤维化的机制与治疗,202301-202612,52万,在研,主持人
3、科技部国家重点研发计划,2020YFC0845100,血必净等中药的评价研究,202003-202012,300万,已结题,主持人
4、广州国家实验室项目,SRPG23-001,新冠奥密克戎变异株肺部感染的病因(原)学临床特征及防治探讨,202301-202312,200万,在研,主持人
5、科技部国家重点研发计划,2023YFC3041700,当前新冠奥密克戎变异株肺部感染患者的病因(原)学、临床特征及防治探讨,645万,在研,主持人
代表性学术论文:
1、Characterization of respiratory microbial dysbiosis in hospitalized COVID-19 patients,CELL DISCOVERY, 2021;
2、Identification and Modulation of Microenvironment Is Crucial for Effective Mesenchymal Stromal Cell Therapy in Acute Lung Injury,AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2019;
3、Kinetics of viral load and antibody response in relation to COVID-19 severity,THE JOURNAL OF CLINICAL INVESTIGATION, 2020;
4、Electrical impedance tomography for titration of positive end-expiratory pressure in acute respiratory distress syndrome patients with chronic obstructive pulmonary disease,CRITICAL CARE, 2022;
5、Multiple approaches for massively parallel sequencing of SARS-CoV-2 genomes directly from clinical samples, GENOME MEDICINE, 2020;
6、Ventilatory Ratio in Hypercapnic Mechanically Ventilated Patients with COVID-19-associated acute respiratory distress syndrome, AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2020;
7、High driving pressure ventilation induces pulmonary hypertension in a rabbit model of acute lung injury, JOURNAL OF INTENSIVE CARE, 2023; 8.A diagnostic model for sepsis-induced acute lung injury using a consensus machine learning approach and its therapeutic implications, JOURNAL OF TRANSLATIONAL MEDICINE, 2023;
8、Mechanical Stress and the Induction of Lung Fibrosis via the Midkine Signaling Pathway, AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2015.
获奖及个人荣誉:
1、国家教委科技进步奖二等奖
2、全国创新争先奖获奖团队
3、广东省抗击非典个人一等功
4、广东省科技进步奖特等奖
5、广东省科技进步奖一等奖
联系方式:
Email: dryiminli@gzhmu.edu.cn