职称：

研究员

研究方向：

主要研究领域包括靶向抗肿瘤药物、核苷类抗病毒药物的研究与开发、抗肿瘤天然产物全合成等。

研究工作：

1、Hsp90受体介导的抗肿瘤靶向药物偶联物的设计、合成及生物活性研究

2、核苷类抗病毒药物的研究与开发

3、基于IDO抑制剂的肿瘤免疫药物发现研究

科研项目：

1、广州市科技计划项目:基于流感耐药病毒的新药研究

2、广州市科技计划项目:针对RNA 病毒复制的核苷衍生物抑制剂的研究

3、中国科学院“个性化药物--基于疾病分子分型的普惠新药研发”战略性先导科技专项:基于IDO抑制剂的肿瘤免疫药物发现研究

代表性学术论文：

1、Cai Lin, Jianchen Yu, Muzammal Hussain, Yiqian Zhou, Anna Duan, Weiqi Pan,Jie Yuan, Jiancun Zhang . Design, synthesis, and biological evaluation of novel 7-deazapurine nucleoside derivatives as potential anti-dengue virus agents . Antiviral Research 149 (2018) 95–105

2、Muzammal Hussain, Yang Zhou, Yu Song, H.M. Adnan Hameed, Hao Jiang,Yaoquan Tu & Jiancun Zhang . ATAD2 in cancer: a pharmacologically challenging but tractable target. Expert Opinion on Therapeutic Targets. 2018,22:1, 85-96

3、Lu Liu, Muzammal Hussain, Jinfeng Luo， Anna Duan，Chaonan Chen， Zhengchao Tu，Jiancun Zhang. Synthesis and biological evaluation of novel dasatinib analogues as potent DDR1 and DDR2 kinase inhibitors.Chemical Biology & Drug Design.2017;89:420–427

4、Cai Lin , Chenghai Sun , Xiao Liu , Yiqian Zhou , Muzammal Hussain ,Junting Wan , Minke Li , Xue Li , Ruiliang Jin , Zhengchao Tu , Jiancun Zhang.Design, synthesis, and in vitro biological evaluation of novel 6-methyl-7-substituted-7-deaza purine nucleoside analogs as anti-influenza A agents.Antiviral Research.January 2016: 129 (2016) 13-20

5、Jian Sun, Cai Lin, Xiaochu Qin ,Xiaoping Dong , Zhengchao Tu , Fei Tang , Chaonan Chen, JiancunZhang. Synthesis and biological evaluation of 3,5-disubstituted-4-alkynylisoxozales as a novel class of HSP90 inhibitors.Bioorganic & Medicinal Chemistry Letters. June 2015: 25 (2015) :3129–3134

联系方式：

Email: zhang_jiancun@gibh.ac.cn