赵金存
职务:
呼吸疾病全国重点实验室主任、广州实验室主任助理
职称:
教授
研究方向:
重大呼吸系统感染和肺损伤
研究工作:
1、呼吸系统病毒进化变异及宿主相互作用机制研究
2、呼吸系统病毒感染天然和获得性免疫答研究
3、呼吸系统传染病疫苗和抗体药物研发
科研项目:
1、国家杰出青年科学基金项目(基金号82025001),2021-2025
2、国家自然科学基金国际(地区)合作与交流项目(组织间合作研究—NSFC-RGC(内地-香港))(基金号8181101118),2019-2022
3、国家自然科学基金组织器官区域免疫特性与疾病重大研究计划(基金号91842106),2019-2021
4、国家重点研发计划《生物安全关键技术研发专项》(基金号2018YFC1200100),2018-2021
5、艾滋病和病毒性肝炎等重大传染病防治科技重大专项(基金号2018ZX10301403-001-003),2018-2021
代表性学术论文:
1、Liu D#, Chen C#, Chen D#, Zhu A#, Li F#, Zhuang Z#, Mok CKP#, Dai J#, Li X#, Jin Y#, Chen Z, Sun J, Wang Y, Li Y, Zhang Y, Wen L, Zhang Z, Zhuo J, Wang J, Ran W, Wang D, Zhang S, Tang Y, Li S, Lai X, Wei P, Yuan J, Chen F, Huang S, Sun F, Qian Z, Tan W, Zhao J, Peiris M*, Zhao J*. Mouse models susceptible to HCoV-229E and HCoV-NL63 and cross protection from challenge with SARS-CoV-2. Proc Natl Acad Sci U S A. 2023 Jan 24;120(4):e2202820120.
2、Wang Y#, Yan A#, Song D#, Dong C, Rao M, Gao Y, Qi R, Ma X, Wang Q, Xu H, Liu H, Han J, Duan M, Liu S, Yu X, Zong M, Feng J, Jiao J, Zhang H, Li M, Yu B, Wang Y, Meng F, Ni X, Li Y, Shen Z, Sun B, Shao X, Zhao H, Zhao Y, Li R, Zhang Y, Du G, Lu J, You C, Jiang H, Zhang L, Wang L*, Dou C*, Liu Z*, Zhao J*. Biparatopic antibody BA7208/7125 effectively neutralizes SARS-CoV-2 variants including Omicron BA.1-BA.5. Cell Discov. 2023 Jan 7;9(1):3.
3、Zhuang Z#, Lai X#, Sun J#, Chen Z#, Zhang Z#, Dai J#, Liu D#, Li Y#, Li F#, Wang Y, Zhu A, Wang J, Yang W, Huang J, Li X, Hu L, Wen L, Zhuo J, Zhang Y, Chen D, Li S, Huang S, Shi Y, Zheng K, Zhong N, Zhao J*, Zhou D*, Zhao J*. Mapping and role of T cell response in SARS-CoV-2-infected mice. J Exp Med. 2021 Apr 5;218(4):e20202187.
4、Zhang Z#, Zeng E#, Zhang L#, Wang W#, Jin Y#, Sun J#, Huang S#, Yin W#, Dai J, Zhuang Z, Chen Z, Sun J, Zhu A, Li F, Cao W, Li X, Shi Y, Gan M, Zhang S, Wei P, Huang J, Zhong N, Zhong G*, Zhao J*, Wang Y*, Shao W*, Zhao J*. Potent prophylactic and therapeutic efficacy of recombinant human ACE2-Fc against SARS-CoV-2 infection in vivo. Cell Discov. 2021 Aug 12;7(1):65.
5、Mok CKP#, Zhu A#, Zhao J#, Lau EHY, Wang J, Chen Z, Zhuang Z, Wang Y, Alshukairi AN, Baharoon SA, Wang W, Tan W, Liang W, Oladipo JO, Perera RAPM, Kuranga SA, Peiris M*, Zhao J*. T-cell responses to MERS coronavirus infection in people with occupational exposure to dromedary camels in Nigeria: an observational cohort study. Lancet Infect Dis. 2021 Mar;21(3):385-395.
6、Sun J#, Zhuang Z#, Zheng J#, Li K#, Wong RL#, Liu D#, Huang J#, He J#, Zhu A#, Zhao J#, Li X#, Xi Y#, Chen R, Alshukairi AN, Chen Z, Zhang Z, Chen C, Huang X, Li F, Lai X, Chen D, Wen L, Zhuo J, Zhang Y, Wang Y, Huang S, Dai J, Shi Y, Zheng K, Leidinger MR, Chen J, Li Y, Zhong N, Meyerholz DK, McCray PB Jr*, Perlman S*, Zhao J*. Generation of a Broadly Useful Model for COVID-19 Pathogenesis, Vaccination, and Treatment. Cell. 2020 Aug 6;182(3):734-743.e5.
7、Wang Y#, Zhang L#, Sang L#, Ye F#, Ruan S#, Zhong B#, Song T#, Alshukairi AN#, Chen R#, Zhang Z, Gan M, Zhu A, Huang Y, Luo L, Mok CK, Al Gethamy MM, Tan H, Li Z, Huang X, Li F, Sun J, Zhang Y, Wen L, Li Y, Chen Z, Zhuang Z, Zhuo J, Chen C, Kuang L, Wang J, Lv H, Jiang Y, Li M, Lin Y, Deng Y, Tang L, Liang J, Huang J, Perlman S, Zhong N, Zhao J*, Malik Peiris JS*, Li Y*, Zhao J*. Kinetics of viral load and antibody response in relation to COVID-19 severity. J Clin Invest. 2020 Oct 1;130(10):5235-5244.
获奖及个人荣誉:
1、《中华医学科技奖》医学科学技术奖,三等奖,排名第二。202203366,中东呼吸综合征冠状病毒病原生物学与免疫学研究及关键技术应用,中国疾病预防控制中心病毒病预防控制所、广州医科大学附属第一医院,谭文杰、赵金存、王文玲、肇静娴、陆柔剑、邓瑶、王延群、黄保英。
2、《全国创新争先奖》,广州医科大学新冠肺炎疫情防控研究南山团队,排名第三,人力资源社会保障部、中国科协、科技部、国务院国资委,2020
联系方式:
Email: zhaojincun@gird.cn