导师介绍
| 姓名 | 李佳 | 性别 | 男 |
| 民族 | 汉族 | 导师层次 | 博士生导师 |
| 职称 | 教授 | 导师类型 | 学术性 |
| 学历 | 博士 | 学位 | 博士研究生 |
| 行政职务 | 无 | 邮箱 | jiali@gzhmu.edu.cn |
| 招生方向 | 生物信息学 | ||
广州医科大学、呼吸疾病国家重点实验室、广州国家实验室PI。截止到2023年3月，共发表SCI论文30余篇。其中以（共同）第一/共一作者或通讯作者在Sci Adv，Nat Commun x3，NAR，JCI，JACS，Am. J. Respir. Crit. Care Med，Brief. Bioinformatics, Gut Microbe, Clin Epigenetics, Stem Cells等高水平杂志发表13篇代表论文（10篇IF>10），累积影响因子超过200，引用超过680次，h-index 18。曾在美国担任助理教授并主持完成一项120美元项目（cfDNA 甲基化）。
计算表观遗传学，主要利用生物信息学方法探索肿瘤发生，发展及耐药的表观分子机制；同时，以此为基础开发新型基于表观分子标记（cfDNA甲基化）的液体活检技术，用以早期检测重大疾病的发生、监测病情发展和评估治疗效果。课题组将利用和开发生物信息学方法，通过系统深入挖掘多组学大数据（单细胞转录组、单细胞表观组、DNA/组蛋白修饰组和染色体3D组等）从多维度深入理解重大疾病的发生的分子机制；依托国家实验室平台以临床应用为目的，研究来自于大规模临床样本的多组学数据，探索呼吸相关疾病的致病机理和开发新的用于早期诊断的呼吸疾病相关的表观生物标记物。
科研项目：
1、2021年南山学者启动资金
2、2023年呼吸疾病国家重点实验室 自主课题一项
3、主持国自然面上项目一项
4、主持全重和广实联合基金一项
5、主持广实专项一项
代表性专利授权：
1、基于图像的甲基化基础模型的细胞类型及占比预测方法和相关设备，CN121191162B
2、基于测序读段的CpG甲基化单细胞全基因组分析方法和相关设备，CN21260264B
代表性学术论文：
1、Yang J, Zhang X, Tang M, Jiang Y, Chen Z, Lai C, Bao J, Su J, Cui D, Li J. Mapping fibroblast plasticity across non-cancer lung diseases at single-cell resolution. Genome Medicine, 2026.
2、Song J, Cui D, Wang J, Qi X, Ma J, Liu Q, Yang J, Yu H, Ye L, Huang Q, et al. Targeting Mettl8–Tcf1 axis promotes CD8⁺ TPEX differentiation and antitumor immunity. Journal of Experimental Medicine, 223(5): e20250424, 2026.
3、Zhang G, Yang Y, Cui D, Li J. DNA Methylation Concurrence, Independent of DNA Methylation Ratios, Is Associated with Chromatin Accessibility and 3D Genome Architecture. International Journal of Molecular Sciences, 26:7199, 2025.
4、Cai Y, Fan Y, Chen A, Wang X, Wang L, Chen J, Wang Z, Li J, Yi X, Ju C. Characteristics of upper and lower respiratory tract microbiota after lung transplantation. Respiratory Research, 26(1):160, 2025.
5、Guo L, Hong T, Lee YT, Hu X, Pan G, Zhao R, Yang Y, Yang J, Cai X, et al. Perturbing TET2 condensation promotes aberrant genome-wide DNA methylation and curtails leukaemia cell growth. Nature Cell Biology, 26:2154–2167, 2024.
6、Cao W, Li J, Che L, Yang R, Wu Z, Hu G, Zou W, Zhao Z, Zhou Y, Jiang X, et al. Single-cell transcriptomics reveals e-cigarette vapor-induced airway epithelial remodeling and injury. Respiratory Research, 25(1):353, 2024.
7、Hong T, Li J, Guo L, Cavalier M, Wang T, Dou Y, DeLaFuente A, Fang S, et al. TET2 modulates spatial relocalization of heterochromatin in aged hematopoietic stem and progenitor cells. Nature Aging, 3(11):1387–1400, 2023.
8、Yang P, Luo Q, Wang X, Fang Q, Fu Z, Li J, Lai Y, Chen X, Xu X, Peng X, et al. Comprehensive analysis of fibroblast activation protein expression in interstitial lung diseases. American Journal of Respiratory and Critical Care Medicine, 207(2):160–172, 2023.
9、Li J, Hong T, Wei Y, Guo L, Lee M, Yang H, Class C, Yang Y, Wang X, et al. Aberrant DNA hydroxymethylation reshapes transcription factor binding in myeloid neoplasms. Clinical Epigenetics, 14(1):81, 2022.
10、Zhao S, Li J, Zhang H, Qi L, Du Y, Kogiso M, Braun FK, Xiao S, Huang Y, et al. Epigenetic alterations of repeated relapses in patient-matched childhood ependymomas. Nature Communications, 13(1):6689, 2022.
11、Li J, Wu X, Ke J, Lee M, Lan Q, Li J, Yu J, Huang Y, Sun DQ, Xie R. TET1 dioxygenase is required for FOXA2-associated chromatin remodeling in pancreatic beta-cell differentiation. Nature Communications, 13(1):3907, 2022.
12、Fang S, Cui D, Hong T, Guo L, Lee YT, Lee M, Isgandarova S, et al. Ten-eleven translocation ablation impairs cardiac differentiation of mouse embryonic stem cells. Stem Cells, 40(3):260–272, 2022.
13、Yin Y, Li J, Li J, Lee M, Zhao S, Guo L, Li J, Zhang M, Huang Y, Li XN, et al. LiBis: an ultrasensitive alignment augmentation for low-input bisulfite sequencing. Briefings in Bioinformatics, 22(4):bbaa332, 2021.
14、Lee M, Li J, Li J, Fang S, Zhang J, Vo ATT, Han W, Zeng H, Isgandarova S, et al. Tet2 inactivation enhances the antitumor activity of tumor-infiltrating lymphocytes. Cancer Research, 81(8):1965–1976, 2021.
15、Han Y, Zhang M, Xu J, Li J, Xu Y, Thompson TC, Logothetis CJ, Sun D, et al. Genome-wide DNA methylation profiling of leukocytes identifies CpG methylation signatures of aggressive prostate cancer. American Journal of Cancer Research, 11(3):968–986, 2021.
16、Chen YS, Li J, Menon R, Jayaraman A, Lee K, Huang Y, Dashwood WM, et al. Reshaping the Gut Microbiome in an Apc-Mutant Genetic Background: Mechanistic Insights From Integrated Multi-Omics. 2021.
17、Li J, Zhao S, Lee M, Yin Y, Li J, Zhou Y, Ballester LY, Esquenazi Y, et al. Reliable tumor detection by whole-genome methylation sequencing of cell-free DNA in cerebrospinal fluid of pediatric medulloblastoma. Science Advances, 6(42):eabb5427, 2020.
18、Bhattacharjee S, Li J, Dashwood RH. Emerging crosstalk between long non-coding RNAs and Nrf2 signaling. Cancer Letters, 490:154–164, 2020.
19、Kumar J, Kaur G, Ren R, Lu Y, Lin K, Li J, Huang Y, Patel A, Barton MC, et al. KRAB domain of ZFP568 disrupts TRIM28-mediated abnormal interactions in cancer cells. NAR Cancer, 2(2):zcaa007, 2020.
20、Li J, Yin Y, Zhang M, Cui J, Zhang Z, Zhang Z, Sun D. GsmPlot: a web server to visualize epigenome data in NCBI. BMC Bioinformatics, 21(1):55, 2020.
获奖及个人荣誉：
1、2019/04: Oral Presentation 1st Award 2019 Annual Student Research Symposium, Texas A&M University Health Science Center
2、2018/10: Oral Presentation, 8th Annual Postdoctoral Science Symposium, MD Anderson Cancer Center
3、2017: Invited Speaker, International Conference on Epigenetics & Bioengineering
4、2017/06: Excellent Research Award for 31th Society of Chinese Bioscientists in America (SCBA-TX) Annual Symposium
5、2014/07: Travel bursary for 34th International Animal Genetic Conference
6、2010-2013: Research Achievement Awards of China Agricultural University
