教授

研究方向：

重大呼吸系统感染和肺损伤

研究工作：

呼吸道重要RNA病毒感染致病机制研究

代表性学术论文：

1、Penghui Jia#, Tian Tian#, Zibo Li, Yicheng Wang, Yuxin Lin, Weijie Zeng, Yu Ye, Miao He, Xiangrong Ni, Ji’an Pan, Xiaonan Dong, Jian Huang, Chun-mei Li*, Deyin Guo* & Panpan Hou*，CCDC50 promotes tumor growth through regulation of lysosome homeostasis，EMBO Rep. 2023 Oct 9;24(10):e56948. doi: 10.15252/embr.202356948. Epub 2023 Sep 6. （最后通讯）

2、Yuxin Lin#; Zibo Li#; Yicheng Wang#; Tian Tian; Penghui Jia; Yu Ye; Miao He; Zixiao Yang; Chunmei Li; Deyin Guo*; Panpan Hou*, CCDC50 suppresses NLRP3 inflammasome activity by mediating autophagic degradation of NLRP3, EMBO Rep. 2022 May 4;23(5): e54453. doi: 10.15252/embr.202154453. （最后通讯）

3、Panpan Hou#, Kongxiang Yang, Penghui Jia, Lan Liu, Yuxin Lin, Zibo Li, Jun Li, Shuliang Chen, Shuting Guo, Ji’An Pan, Junyu Wu, Hong Peng, Weijie Zeng, Chunmei Li, Yingfang Liu and Deyin Guo*，A novel selective autophagy receptor, CCDC50, delivers K63 polyubiquitination-activated RIG-I/MDA5 for degradation during viral infection，Cell Res. 2021 Jan;31(1):62-79. doi: 10.1038/s41422-020-0362-1. Epub 2020 Jul 1. （独立一作）

4、Panpan Hou#, Penghui Jia#, Kongxiang Yang#, Zibo Li, Tian Tian, Yuxin Lin, Weijie Zeng, Fan Xing, Yu Chen, Chunmei Li, Yingfang Liu & Deyin Guo*，An unconventional role of an ASB family protein in NF-κB activation and inflammatory response during microbial infection and colitis， Proc Natl Acad Sci U S A. 2021 Jan 19;118(3): e2015416118. doi: 10.1073/pnas.2015416118. （共一排一）

5、Panpan Hou#, Yuxin Lin#, Zibo Li#, Tian Tian, Yicheng Wang, Penghui Jia, Xi Zhang, Liu Cao, Chunmei Li, Jieruo Gu & Deyin Guo*，Autophagy receptor CCDC50 tunes STING-mediated interferon response in viral infection and autoimmune disease, Cell Mol Immunol. 2021 Dec;18(12):2682. doi: 10.1038/s41423-021-00777-7. （共一排一）

6、Panpan Hou# ; Chao Wu# ; Yuchen Wang; Rui Qi; Dheeraj Bhavanasi;Zhixiang Zuo; Cedric Dos Santos; Shuliang Chen; Yu Chen; Hong Zheng; Hong Wang;Alexander Perl; Deyin Guo; Jian Huang*，A Genome-Wide CRISPR Screen Identifies Genes Critical for Resistance to FLT3 Inhibitor AC220, Cancer Research, 2017.8.15, 77(16): 4402~4413 （共一排一）

7、Panpan Hou#；Tian Tian；Penghui Jia； Yuxin Lin； Zibo Li；Yicheng Wang； Yu Ye； Chunmei Li； Deyin Guo*，The regulation of NLRP3 inflammasome activation by CCDC50-mediated autophagy，Autophagy，2022 May 27;1-2. doi: 10.1080/15548627.2022.2080957. （独立一作）

联系方式：

Email: houpp@mail.sysu.edu.cn