职称：

研究员

研究方向：

重大呼吸系统感染和肺损伤

研究工作：

聚焦人呼吸道病毒与宿主之间的相互作用，从宿主限制因子和依赖因子两个角度着重探究重要呼吸道病毒的传播机制；通过功能基因组学方法揭示冠状病毒和流感病毒发生跨种传播的分子机制：

1、重要呼吸道病毒膜入侵和传播机制；

2、冠状病毒和流感病毒发生跨种传播的分子机理。

代表性学术论文：

1、Wang S#, Li W#, Hui H, Tiwari SK, Zhang Q, Croker BA, Rawlings S, Smith D, Carlin AF, Rana TM* (2020) Cholesterol 25-Hydroxylase inhibits SARS-CoV-2 and other coronaviruses by depleting membrane cholesterol. The EMBO J 39: e106057. (#co-first authors)

2、Wang L#, Wang S#, Wu L, Li W, Bray W, Clark AE, Gonzalez GM, Wang Y, Carlin AF, Rana TM* (2023) PCIF1-mediated deposition of 5'-cap N6, 2'-O-dimethyladenosine in ACE2 and TMPRSS2 mRNA regulates susceptibility to SARS-CoV-2 infection. Proceedings of the National Academy of Sciences 120 (5), e2210361120. (#co-first authors)

3、Wang S#, Zhang Q#, Tiwari SK#, Lichinchi G, Yau EH, Hui H, Li W, Furnari F, Rana TM* (2020) Integrin alphavbeta5 Internalizes Zika Virus during Neural Stem Cells Infection and Provides a Promising Target for Antiviral Therapy. Cell Reports 30: 969-983 e4. ( #co-first authors) (Highlighted by a Preview from Cell Stem Cell)

4、Zhang Q#, Wang S#, Li W, Yau E, Hui H, Singh P, Achuthan V, Karris M, Engelman A, Rana TM* (2022). Genome-wide CRISPR/Cas9 transcriptional activation screen identifies a histone acetyltransferase inhibitor complex as a regulator of HIV-1 integration. Nucleic Acids Research 50 (12), 6687-6701 (#co-first authors)

5、Zhang LJ#, Wang S#, Xia L, Lv C, Tang HW, Liang Z, Xiao G*, Pang DW* (2020) Lipid-Specific Labeling of Enveloped Viruses with Quantum Dots for Single-Virus Tracking. mBio 11(3). ( #co-first authors)

6、Wang S#, Zhang Q#, Hui H, Agrawal K, Karris MAY, Rana TM* (2020) An atlas of immune cell exhaustion in HIV-infected individuals revealed by single-cell transcriptomics. Emerging microbes & infections 9(1), 2333-2347.( #co-first authors)

7、Wang S, Liu Y, Guo J, Wang P, Zhang L, Xiao G, Wang W* (2017) Screening of FDA-approved drugs for inhibitors of Japanese encephalitis virus infection. Journal of Virology 91(21):e01055-17. (Faculty 1000 Recommendation)

8、Wang S, Liu H, Zu X, Liu Y, Chen L, Zhu X, Zhang L, Zhou Z, Xiao G*, Wang W* (2016) The ubiquitin-proteasome system is essential for the productive entry of Japanese encephalitis virus. Virology 498:116-127.

9、Yu S, Hu H, Ai Q, Bai R, Ma K, Zhou M, Wang S* (2023) SARS-CoV-2 Spike-Mediated Entry and Its Regulation by Host Innate Immunity. Viruses 15(3), 6.

联系方式：

Email: wang_shaobo@gzlab.ac.cn