教授

研究方向：

重大呼吸系统感染和肺损伤

研究工作：

运用生物化学与结构生物学方法长期从事病原微生物的感染，传播，及致病机制的研究

科研项目：

1、解析分枝杆菌重要生理过程及结核分枝杆菌免疫逃逸中关键蛋白质机器的分子基础 2021YFA1300903 结核分枝杆菌致病与耐药相关蛋白质机器研究 2021-2026 577万元

代表性学术论文：

1、1.He, P.#, Liu, B.#, Gao, X.#, Yan, Q.#, Pei, R.#, Sun, J., Chen, Q., Hou, R., Li, Z., Zhang, Y., Zhao, J., Sun, H., Feng, B., Wang, Q., Yi, H., Hu, P., Li, P., Zhang, Y., Chen, Z., Niu, X., Zhong, X., Jin, L., Liu, X., Qu, K., Ciazynska, K.A., Carter, A.P., Briggs, J.A.G., Chen, J., Liu, J., Chen, X.*, He, J.*, Chen, L.*, Xiong, X.* (2022) SARS-CoV-2 Delta and Omicron variants evade population antibody response by mutations in a single spike epitope. Nature Microbiology 7: 1635-1649

2、Xiong, X.#*, Qu, K.#, Ciazynska, K.A., Hosmillo, M., Carter, A.P., Ebrahimi, S., Ke, Z., Scheres, S.H.W., Bergamaschi, L., Grice, G.L., Zhang, Y., The CITIID-NIHR COVID-19 BioResource Collaboration, Nathan, J.A., Baker, S., James, L.C., Baxendale, H.E., Goodfellow, I., Doffinger, R., Briggs, J.A.G.* (2020) A thermostable, closed SARS-CoV-2 spike protein trimer. Nature Structural & Molecular Biology 27: 934-941

3、Peukes, J.#, Xiong, X.#*, Erlendsson, S., Qu, K., Wan, W., Calder, L.J., Schraidt, O., Kummer, S., Freund, S.M.V., Krausslich, H.G., Briggs, J.A.G.* (2020) The native structure of the assembled matrix protein 1 of influenza A virus. Nature 587: 495-498

4、Walls, A.C.#, Xiong, X.#, Park, Y.J., Tortorici, M.A., Snijder, J., Quispe, J., Cameroni, E., Gopal, R., Dai, M., Lanzavecchia, A., Zambon, M., Rey, F.A., Corti, D., Veesler, D. (2019) Unexpected Receptor Functional Mimicry Elucidates Activation of Coronavirus Fusion. Cell 176: 1026-1039.e1015

5、Xiong, X.#, Coombs, P.J.#, Martin, S.R.#, Liu, J., Xiao, H., McCauley, J.W., Locher, K., Walker, P.A., Collins, P.J., Kawaoka, Y., Skehel, J.J., Gamblin, S.J. (2013a) Receptor binding by a ferret-transmissible H5 avian influenza virus. Nature 497: 392-396

6、Xiong, X., Martin, S.R., Haire, L.F., Wharton, S.A., Daniels, R.S., Bennett, M.S., McCauley, J.W., Collins, P.J., Walker, P.A., Skehel, J.J., Gamblin, S.J. (2013) Receptor binding by an H7N9 influenza virus from humans. Nature 499: 496-499

获奖及个人荣誉：

1、海外高层次人才计划青年项目 2020

2、广东省珠江人才计划 2020

联系方式：

Email: xiong_xiaoli@gibh.ac.cn