研究员

研究方向：

重大呼吸系统感染和肺损伤

研究工作：

从宿主角度阐述呼吸道病毒感染造成急性肺损伤及疾病慢性化机制，开发广谱抗病毒药物、发现促进肺损伤修复靶点并进行药物开发。

1、组建儿童肺炎专病队列，挖掘潜在的致病风险基因。

2、构建动物模型，阐述重症肺炎风险基因作用机制。

3、根据所发现的致病机制，开发广谱抗病毒药物。

代表性学术论文：

1、Ming Liu*#, Bingtai Lu#, Yue Li#, Shuofeng Yuan#, Zhen Zhuang#, Guangyu Li, Liuheyi Ma, Jianheng Zhu, Jinglu Zhao, Chris Chung-Sing Chan, Vincent Kwok-Man Poon, Kenn Ka-Heng Chik, Zhiyao Zhao, Huifang Xian, Jingxian Zhao, Jincun Zhao*, Jasper Fuk-Woo Chan*, Yuxia Zhang*. P21-activated kinase 1 (PAK1)-mediated cytoskeleton rearrangement promotes SARS-CoV-2 entry and ACE2 autophagic degradation. Signal Transduc. Target. Ther. 2023; 8(1):385

2、Xiaoyan Liu, Zhe Li, Shuai Liu, Jing Sun, Zhanghua Chen, Min Jiang, Qingling Zhang, Yinghua Wei, Xin Wang, Yi-You Huang, Yinyi Shi, Yanhui Xu, Huifang Xian, Fan Bai, Changxing Ou, Bei Xiong, Andrew M Lew, Jun Cui, Rongli Fang, Hui Huang, Jincun Zhao*, Xuechuan Hong*, Yuxia Zhang*, Fuling Zhou*, Hai-Bin Luo*. Potential therapeutic effects of dipyridamole in the severely ill patients with COVID-19. Acta Pharm Sin B. 2020; 10(7):1205-1215

3、Bingtai Lu, Ming Liu, Jun Wang, Huifeng Fan, Diyuan Yang, Li Zhang, Xiaoqiong Gu, Junli Nie, Zhenjun Chen, Alexandra J Corbett, Michael J Zhan, Shengbo Zhang, Vanessa L Bryant, Andrew M Lew, James McCluskey, Hai-bin Luo, Jun Cui, Yuxia Zhang*, Yifan Zhan*, Gen Lu*.IL-17 production by tissue-resident MAIT cells is locally induced in children with pneumonia. Mucosal Immunol. 2020; 13(5):824-835

联系方式：

Email: yuxia.zhang@gwcmc.org