职称：

教授

研究方向：

慢性气道疾病

研究工作：

主要从事过敏性哮喘和肺损伤等炎性呼吸系统疾病的免疫学和组学研究。

1、儿童过敏性哮喘中神经免疫调节机制；

2、多组学分析鉴定儿童过敏性哮喘激素耐受机制和药物新靶点；

3、CRISPR筛选儿童过敏性哮喘和肺感染中组织定居记忆性T细胞关键调控因子；

4、靶向组织定居记忆性T细胞关键调控因子小分子药物筛选。

代表性学术论文：

1、Kamakshi Bankoti*, Wei Wang*, Gaurang M. Amonkar, Linjie Xiong, Jessica E. Shui, Mwase Chimwemve, Jin-Ah Park, Hongmei Mou, Yinshan Fang, Jianwen Que, Yan Bai, Paul H. Lerou and Xingbin Ai. Airway basal stem cells in COVID-19 exhibit a proinflammatory signature and impaired mucocililary differentiation. American Journal of Respiratory Cell and Molecular Biology (IF=6.4). 2023 Sep 12. doi: 10.1165/rcmb.2023-0104OC. (co-first author)

2、Jianye Deng*, Hong-Jin Zhao*, Ying Zhong*, Cuiping Hu, Shiqin Zhu, Jinlai Meng, Chunling Wang, Xiangxin Lan, Xiyao Wang, Zi-Jiang Chen, Junhao Yan†, Wei Wang†, Yan Li†. H3K27me3-regulated Human Trophoblast BMP2 Signaling Enhancement Can Alleviate Shallow Trophoblast Invasion in Preeclampsia. eBioMedicine (IF=11.1). 2023 Jun 16;93:104664. (Co-corresponding author)

3、Wei Wang*†, Carolyn Garcia, Fengzhi Shao, Jonathan A. Cohen, Yan Bai, Alan Fine and Xingbin Ai. Lung dopaminergic nerves facilitate the establishment of TH2 resident memory cells in early life. Journal of Allergy and Clinical Immunology (IF=14.2). 2023 Aug 3;152(23):386-99. (First author and co-corresponding author)

4、Wei Wang*, Jonathan A. Cohen, Antonia Wallrapp, Kenneth G. Trieu, Juliana Barrios, Fengzhi Shao, Nandini Krishnamoorthy, Vijay K. Kuchroo, Matthew R. Jones, Alan Fine, Yan Bai, Xingbin Ai. Age-related dopaminergic innervation augments T helper 2-type allergic inflammation in the postnatal lung. IMMUNITY (IF=32.4). 2019 Dec 17;51(6):1102-1118.e7.

5、Wei Wang*†, Xingbin Ai. Primary culture of immature, naïve mouse CD4+ T cells. STAR Protocols. 2021 Aug 14;2(3):100756. (First author and co-corresponding author)

6、Wei Wang*, Penghui Yang*, Ying Zhong*, Zhongpeng Zhao, Li Xing, Yan Zhao, Zhen Zou, Yanli Zhang, Chenggang Li, Taisheng Li, Chen Wang, Zhong Wang, Xuezhong Yu, Bin Cao, Xiang Gao, Josef M. Penninger, Xiliang Wang and Chengyu Jiang. Monoclonal antibody against CXCL-10/IP-10 ameliorates influenza A (H1N1) virus induced acute lung injury. Cell Research (IF=44.1). 2013 Apr;23(4):577-80.

7、JingGuo*, Fengming Huang*, Jun Liu*, Yu Chen*, Wei Wang*, Bin Cao*, Zhen Zou, Song Liu, Jingcao Pan, Changjun Bao, Mei Zeng, Haixia Xiao, Hainv Gao, Shigui Yang, Qiang Liu, Huandi Zhou, Jingdong Zhu, Xiaoli Liu, Weifeng Liang, Yida Yang, Shufa Zheng, Jiezuan Yang, Hongyan Diao, Kunkai Su, Li Shao, Hongcui Cao, Ying Wu, Min Zhao, Shuguang Tan, Hui Li, Xiaoqing Xu, Chunmei Wang, Jianmin Zhang, Li Wang, Jianwei Wang, Jun Xu, Dangsheng Li, Nanshan Zhong, Xuetao Cao, George F. Gao, Lanjuan Li and Chengyu Jiang. The Serum Profile of Hypercytokinemia Factors Identified in H7N9-Infected Patients can Predict Fatal Outcomes. Scientific Reports (IF=4.6). 2015 Jun 1;5:10942. (Co-first author)

8、Yihan Zhang*, Katharine Black, Thien-Khoi N Phung, Tian Lin, Wei Wang, Jie Xu, Brittany Wilson-Mifsud, Cheng Zhang, Lida P Hariri, Allen Lapey, Hu Li, Paul Lerou, Xingbin Ai, Jianwen Que, Jin-Ah Park, Bryan P Hurley and Hongmei Mou. Human airway basal cells undergo reversible squamous differentiation and reshape innate immunity. American Journal of Respiratory Cell and Molecular Biology (IF=6.4). 2023 Jun;68(6):664-678.

9、Richard Wagner*, Gaurang M. Amonkar*, Wei Wang, Jessica E. Shui, Kamakshi Bankoti, Andrew Tse, Frances A. High, Augusto Zani, Richard Keijzer, Patricia K. Donahoe, Paul H. Lerou, Xingbin Ai. A tracheal aspirate-derived airway basal cell model reveals a proinflammatory epithelial defect in congenital diaphragmatic hernia. American Journal of Respiratory and Critical Care Medicine (IF=24.7). 2023 May 1;207(9):1214-1226.

10、Jessica E. Shui*, Wei Wang, Helu Liu, Anna Stepanova, Grace Liao, Jun Qian, Xingbin Ai, Vadim Ten, Jining Lu, Wellington V. Cardoso. Prematurity alters the progenitor cell program of the upper respiratory tract of neonates. Scientific Reports (IF=4.6). 2021 May 24;11(1):10799.

联系方式：

Email: wangwei0429@gmail.com