王璋-全体研究人员-人才队伍-呼吸疾病全国重点实验室

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人才队伍

全体研究人员 • 学术带头人

人才队伍全体研究人员

王璋

职称：

研究员

研究方向：

慢性气道疾病

研究工作：

主要从事呼吸道微生物组作为呼吸疾病新型生物标志物及潜在干预靶标。

科研项目：

1、十四五国家重点研发计划课题，《呼吸道微生物组数据收集及分析方法学研究》，370万元，2022YFA1304301，主持，2022.12-2027.11

2、国家自然科学基金面上项目，《慢性阻塞性肺疾病气道菌群失调促进脓毒症急性肺损伤的机制探索》，58万元，32170109，主持，2022.1-2025.12

3、国家自然科学基金面上项目，《多组学技术联合解析慢阻肺急性加重气道微生物组宿主互作机制》，62万元，31970112，主持，2020.1-2023.12

代表性学术论文：

1、Lin L#1, Yi X1, Liu H1, Meng R1, Li S, Liu X, Yang J, Xu Y, Li C, Wang Y, Xiao N, Li H, Liu Z, Xiang Z, Shu W, Guan WJ#, Zheng XY#, Sun J#, Wang Z#. The airway microbiome mediates the interaction between environmental exposure and respiratory health in humans. 2023. Nature Medicine. Jul;29(7):1750-1759. doi: 10.1038/s41591-023-02424-2

2、Liang W1, Yang Y1, Gong S1, Wei M1, Ma Y1, Feng R, Gao J, Liu X, Tu F, Ma W, Yi X, Liang Z, Wang F, Wang L, Chen D, Shu W, Miller BE, Tal-Singer R, Donaldson GC, Wedzicha JA, Singh D, Wilkinson TMA, Brightling CE, Chen R, Zhong N, Wang Z#. Airway dysbiosis accelerates lung function decline in chronic obstructive pulmonary disease. 2023. Cell Host & Microbe. May 16:S1931-3128(23)00167-1. doi: 10.1016/j.chom.2023.04.018

3、Yan Z1, Chen B1, Yang Y1, Yi X1, Wei M1, Ecklu-Mensah G, Bushmann M, Liu H, Gao J, Liang W, Liu X, Yang J, Ma W, Liang Z, Wang F, Chen D, Wang L, Shi W, Stampfli MR, Li P, Gong S, Chen X, Shu W, El-Omar EM, Gilbert JA, Blaser MJ, Zhou H#, Chen R#, Wang Z#. Multi-omics analyses of airway host-microbe interactions in chronic obstructive pulmonary disease identify potential therapeutic interventions. Nature Microbiology. 2022. Sep;7(9):1361-1375. doi: 10.1038/s41564-022-01196-8

4、Wang Z#, Locantore N, Haldar K, Ramsheh MY, Beech AS, Ma W, Brown JR, Tal-Singer R, Barer MR, Bafadhel M, Donaldson GC, Wedzicha JA, Singh D, Wilkinson TMA, Miller BE, Brightling CE. Inflammatory Endotype Associated Airway Microbiome in COPD Clinical Stability and Exacerbations – A Multi-Cohort Longitudinal Analysis. American Journal of Respiratory and Critical Care Medicine. 2021 Jun 15;203(12):1488-1502

5、Wang Z1, Bafadhel M1, Haldar K, Spivak A, Mayhew D, Miller BE, Tal-Singer R, Johnston SL, Ramsheh MY, Barer MR, Brightling CE, Brown JR. 2016. Lung microbiome dynamics in chronic obstructive pulmonary disease exacerbations. European Respiratory Journal. Apr;47(4):1082-92.

6、Wang Z1#, Yang Y1, Yan Z1, Liu H, Chen B, Liang Z, Wang F, Miller BE, Tal-Singer R, Yi X, Li J, Stampfli MR, Zhou H, Brightling CE, Brown JR, Wu M, Chen R, Shu W. Multi-omic meta-analysis identifies functional signatures of airway microbiome in chronic obstructive pulmonary disease. The ISME Journal. 2020 Nov;14(11):2748-2765

7、Wang Z1, Singh R1, Miller BE, Tal-Singer R, Van Horn S, Tomsho L, Mackay A, Allinson JP, Webb AJ, Brookes AJ, George LM, Barker B, Kolsum U, Donnelly LE, Belchamber K, Barnes PJ, Singh D, Brightling CE, Donaldson GC, Wedzicha JA, Brown JR on behalf of COPDMAP. 2018. Sputum microbiome temporal variability and dysbiosis in chronic obstructive pulmonary disease exacerbations: an analysis of the COPDMAP study. Thorax. Apr;73(4):331-338