职务：

深圳大学过敏反应与免疫学研究所所长、呼吸疾病全国重点实验室深圳大学过敏反应分室主任

职称：

教授

研究方向：

慢性气道疾病

研究工作：

主要从事免疫调节、呼吸道过敏反应发病原理和免疫耐受的研究工作。

科研项目：

1、重大项目：异种心脏移植免疫排斥早期诊断标准制定和免疫耐受的诱导。2021-2025；300万元。

2、抗原/VIP融合蛋白疫苗调节肠粘膜免疫耐受、抑制食物过敏反应的机理研究. 2016-2019；60万元。

3、表达TSP1的耐受型B细胞抑制食物过敏反应的作用机理研究. 2014-2017；70万元。

4、抗IgE-ε链单克隆抗体对实验性过敏反应的抑制作用研究. 1992-1995；4万元。

代表性学术论文：

1、Jianli Lin#, Nana Huang#, Jing Li#, Xiaoyu Liu#, Qing Xiong, Chengshen Hu, Desheng Chen, Lvxin Guan, Kexin Chang, Dan Li, Stephen Kwok-Wing Tsui, Nanshan Zhong*（钟南山）, Zhigang Liu*, Ping-Chang Yang*. Cross-reactive antibodies against dust mite-derived enolase induce neutrophilic airway inflammation. Eur Respir J. 2021 Jan 28;57(1):1902375.

2、Gui Yang, Xian-Hai Zeng, Xiao-Rui Geng, Jiang-Qi Liu, Li-Hua Mo Xiang-Qian Luo, Hua-Zhen Liu, Yuan-Yi Zhang, Li-Teng Yang, Qin-Miao Huang, Xiao-Jun Xiao, Jie Liu, Ling-Zhi Xu, Da-Bo Liu, Xiao-Yu Liu, Zhi-Qiang Liu, Ping-Chang Yang. The transcription factor XBP1 in dendritic cells promotes the TH2 cell response in airway allergy. Science Signaling 2023 June 7; 16(791):eabm9454.

3、Liu XY#, Wu YJ#, Song LJ#, Zeng XH, Wang S, Liu JQ, Mo LH, Geng XR, Yang LT, Zhang XW*, Liu ZG*, Yang PC*. 3-methyl-4-nitrophenol regulates dendritic cell activities to facilitate the development of nasal allergy. J Allergy Clin Immunol 2019 Apr;143(4):1614-1616.

4、Liu ZQ#, Feng Y#, Mo LH#, Zeng XH, Liu JQ, Xie RD, Liu ZG, Yang PC*, Zhang GJ*, Wu SD*. Bcl2L12 plays a critical role in the development of airway allergy via inducing aberrant T helper-2 polarization. J Allergy Clin Immunol 2019 Jan;143(1):427-430.

5、Sun X, Guo C, Zhao F, Zhu J, Xu Y, Liu ZQ, Yang G, Zhang YY, Xiao L, Liu Z*, Yang PC*. Vasoactive intestinal peptide stabilizes intestinal immune homeostasis through maintaining interleukin-10 expression in regulatory B cells. Theranostics 2019; 9 (10): 2800-2811.

6、Zheng PY, Geng XR, Hong JY, Yang G, Liu JQ, Mo LH, Feng Y, Zhang YY, Liu T, Ran P, Liu ZG*, Yang PC*. Regulating Bcl2L12 expression in mast cells inhibits food allergy. Theranostics. 2019; 9 (17): 4982-4992.

7、Zhou LB#, Zheng YM#, Liao WJ#, Song LJ#, Meng X#, Gong X, Chen G, Liu WX, Wang YQ, Han DM, Zhong NS, Lu W*, Yang PC*, Zhang XW*. MUC1-deficiency promotes nasal epithelial barrier dysfunction in subjects with allergic rhinitis. J Allergy Clin Immunol 2019; 144(6):1716-1719.

8、Chen X#, Zeng XH#, Wang M, Chen L, Zhang N, Rao M, Yang PC*, Song J*. Bcl2 like protein 12 is required for the aberrant T helper-2 polarization in the heart by enhancing interleukin-4 expression and compromising apoptotic machinery in CD4+ T cells. Circulation 2018 July. 138 (27): 2559–2568.

联系方式：

Email: Pcy2356@163.com