全体研究人员 学术带头人

姚茂金

职称:

教授

研究方向:

肺癌

研究工作:

1、肺部发育与肺相关疾病方向:解析肺部自主神经系统发育起源及机制,阐明其在气道炎症相关疾病中的作用及机制。

2、肺癌方向:基于EGFR突变肺癌小鼠模型,阐明不同细胞起源的早期肺癌肿瘤微环境异质性演化机制。

科研项目:

1、国家自然科学基金,面上项目,ZEB2调控肿瘤细胞转分化星形胶质细胞的分子机制研究,项目编号:82072787,55万元,2021.01-2024.12,在研,主持。

2、广州市科技局市校(院)联合资助项目基础与应用基础研究项目(南山基金项目),神经元来源IGF1促进肺癌脑转移的细胞分子机制研究,项目编号:202102010368,25万元,2020.11-2022.10,结题,主持。

3、广州市教育局,“羊城学者”高校科研项目,肿瘤演进与诊疗的可视化研究,15万元,项目编号:202235421 ,2023.01.01-2024.12.31,在研,主持。

代表性学术论文:

1、Maojin Yao, P. Britten Ventura, Ying Jiang, Fausto J. Rodriguez, Lixin Wang, Justin S. A. Perry, Yibo Yang, Kelsey Wahl, Rowena B. Crittenden, Mariko L. Bennett, Lin Qi, Cong-Cong Gong, Xiao-Nan Li, Ben A. Barres, Timothy P. Bender, Kodi S. Ravichandran, Kevin A. Janes, Charles G. Eberhart, Hui Zong. Astrocytic trans-differentiation completes a multicellular paracrine feedback loop required for medulloblastoma tumor growth. Cell. 2020 Feb 6;180(3):502-520

2、Chuanli Hou, Yang Hu, Hong Jiang, Zhenzhen Xu, Wanqian Sha, Juncheng Liu,Jiaoyan Ren*, Maojin Yao*.Establishment of a 3D hyperuricemia model based on cultured human liver organoids.Free Radical Biology and Medicine.2021 Nov 22;178:7-17

3、Luo T, Liu Y, Yao M*. Social Jet Lag, Weekend Warriors, and Physical Activity Patterns. JAMA Intern Med. 2023 Jan 1;183(1):87, JCR 1区,IF= 44.411

4、Hu Y, Li Z, Zhang Y, Wu Y, Liu Z, Zeng J, Hao Z, Li J*, Ren J*, Yao M*. The Evolution of Tumor Microenvironment in Gliomas and Its Implication for Target Therapy. Int J Biol Sci 2023,19(13):4311-4326.

5、Maojin Yao, Shu Li, Xiaojun Wu, Shuo Diao, Guoxin Zhang, Hua He, Liuguan Bian, Yicheng Lu. Cellular origin of glioma and its implication in precision therapy. Cellular & Molecular Immunology. 2018.May;15(8)737-739

6、He H, Yao M, Zhang W, Tao B, Liu F, Li S, Dong Y, Zhang C, Meng Y, Li Y, Hu G, Luo C, Zong H, Lu Y. MEK2 is a prognostic marker and potential chemo-sensitizing target for glioma patients undergoing temozolomide treatment. Cellular & Molecular Immunology .2016, 13(5)658–668

联系方式:

Email: maojin.yao@aliyun.com