科研项目
1、气道上皮纤毛细胞源性外泌体参与 COPD 疾病进程的作用机制;
2、基于创新的外泌体提取检测技术联合影像组学建立早期预测肺纤维化进展的模型;
3、心梗时心肌细胞来源外泌体 miRNA-146a-5p 诱导巨噬细胞分化机制的研究;
4、虎杖苷在小鼠冠状动脉缺血再灌注损伤中的保护作用及其机制研究;
5、缺氧诱导有丝分裂因子 HIMF 通过抑制 SUV39H1-H3K9me3 促进巨噬细胞向 M1 表型转化加重心 肌梗死损伤的作用和机制研究。
6、外泌体在呼吸系统疾病及肺癌中的早筛与伴随诊断平台研发。
代表性成果
1、Dong M* DADA-EV: domain-adaptive diusion autoencoder for estimating tissue- and cell-type-specific origin in extracellular vesicle transcriptomes. Briefings in Bioinformatics. (2026)(IF=7,生物学2区,数学与计算生物学1区,通讯作者)
2、Dong M* Non-destructive bio-fabrication of gadolinium oxide-encapsulated exosomes via bioreactor culture for enhanced MR angiography with efficient renal clearance. Chemical Engineering Journal(2025) 170821(IF=13.2, 工程技术1区,通讯作者)
3、Dong M* Macrophage‐derived Extracellular Vesicles Disguised AIEgen/IDO1 Inhibitor Nanoplatform Reactivate “Immune‐Hot” for Photothermal Immunotherapy via Multi‐Dimensionally Reprograms Tumor Microenvironment. Aggregate (2025)e70175. (IF13.7, 化学1区,通讯作者)
4、Dong M# The exosomal protein biomarkers auxiliary in diagnosis of interstitial lung disease. Respiratory Research (2025)26, 255. (IF5,医学2区,共一第一作者)
5、Dong M* Accurate and Convenient Lung Cancer Diagnosis through Detection of Extracellular Vesicle Membrane Proteins via Förster Resonance Energy Transfer. Nano Letters (2023)23, 8115-8125. (IF10.8,材料科学1区[Top],通讯作者)