职称：

研究员

研究方向：

肺癌

研究工作：

运用药物化学和化学生物学等学科的技术手段发现生物活性小分子并将其应用于化学生物学基础研究和创新药物发现，特别是针对恶性肿瘤和代谢性疾病等疾病的新型靶标进行新分子实体发现和临床前研究。包括：

1、恶性肿瘤、代谢性疾病等疾病的药物研发；

2、生物活性工具分子的设计合成和应用研究；

3、小分子药物的合成策略和工艺优化；

代表性学术论文：

1、Wu T#, Li ST#, Ran Y#, Lin Y, Liu L, Zhang X, Zhou L, Zhang L, Wu D, Yang B*, Tang S*. Mapping protein direct interactome of oxidoreductases with small molecular chemical cross-linkers in live cells. Redox Biol. 2023 May;61:102642.

2、Qin Y#, Tang S#, Zhen G, Ding Q, Ding S, Cao X. Bone-targeted delivery of TGF-β type 1 receptor inhibitor rescues uncoupled bone remodeling in Camurati-Engelmann disease. Ann N Y Acad Sci. 2018 Dec; 1433(1):29-40. PMID: 30091466 (#equal contribution)

3、Hou L#, Yang G#, Tang S#, Alcazar C, Joshi P, Strassberg Z, Kim M, Kawamura M, Woo YJ, Shrager J, Ding S, Huang NF. A small molecule derived from carboxyethylpyrrole protein adducts promotes angiogenesis in a mouse model of peripheral arterial disease. J Am Heart Assoc. 2018 Sep 18;7(18):e009234. PMID: 30371212 (#equal contribution)

4、Yang B#, Tang S#, Ma C#, Li ST, Shang GC, Dang B, DeGrado WF, Dong MQ, Wang PG, Ding S, Wang L. Spontaneous and specific chemical cross-linking in live cells to capture and identify protein interactions. Nat Commun. 2017 Dec 21;8(1):2240. PMID: 29269770 (#equal contribution)

5、Tang S#, Xie M#, Cao N, Ding S. Patient-specific induced pluripotent stem cells for disease modeling and phenotypic drug discovery. J Med Chem. 2016 Jan 14; 59(1):2-15. PMID: 26322868. (#equal contribution)

联系方式：

Email: tang_shibing@gibh.ac.cn