职称：

主任医师

研究方向：

间质性肺病和肺血管病

研究工作：

主要从事肺动脉高压、肺栓塞及不明原因呼吸困难等肺血管疾病的诊断、药物靶向治疗及发病机制的相关研究。

科研项目：

1、HIF-2α-Snail调节环路在肺血管内皮转化过程中的作用机制研究， 国家自然科学基金，面上项目，54万，2019

2、AQP1在低氧性肺动脉高压发病过程中的作用机制研究， 国家自然科学基金，青年项目，21.6万，2015

代表性学术论文：

1、Jain PP#, Lai N#, Xiong M, Chen J, Babicheva A, Zhao T, Parmisano S, Zhao M, Paquin C, Matti M, Powers R, Balistrieri A, Kim NH, Valdez-Jasso D, Thistlethwaite PA, Shyy JY, Wang J, Garcia JGN, Makino A, Yuan JX*. TRPC6, a Therapeutic Target for Pulmonary Hypertension. Am J Physiol Lung Cell Mol Physiol. 2021 Oct 27. doi: 10.1152/ajplung.00159.2021. Online ahead of print.

2、Pritesh P. Jain, Tengteng Zhao, Mingmei Xiong, Shanshan Song, Ning Lai, Shane G. Carr, Aleksandra Babicheva, Marisela Rodriguez, Shamin Rahimi, Francesca Balistrieri, Tatum Simonson, Daniela Valdez-Jasso, Patricia A. Thistlethwaite, John Y.-J. Shyy, Jian Wang, Ayako Makino and Jason X.-J. Yuan. Halofuginone, a Promising Drug for Treatment of Pulmonary Hypertension, Br J Pharmacol. 2021 Mar 10. doi: 10.1111/bph.15442.

3、Xiong M, Jain PP, Chen J, Babicheva A, Zhao T, Alotaibi M, Kim NH, Lai N, Izadi A, Rodriguez M, Li J, Balistrieri A, Balistrieri F, Parmisano S, Sun X, Voldez-Jasso D, Shyy JY, Thistlethwaite PA, Wang J, Makino A, Yuan JX. Mouse model of experimental pulmonary hypertension: Lung angiogram and right heart catheterization. Pulm Circ. 2021 Sep 8;11(4):20458940211041512.

4、Zhang Q, Tsuji-Hosokawa A, Willson C, Watanabe M, Si R, Lai N, Wang Z, Yuan JX, Wang J, Makino A. Chloroquine differentially modulates coronary vasodilation in control and diabetic mice. Br J Pharmacol. 2020 Jan;177(2):314-327.

5、Si R, Zhang Q, Tsuji-Hosokawa A, Watanabe M, Willson C, Lai N, Wang J, Dai A, Scott BT, Dillmann WH, Yuan JX, Makino A. Overexpression of p53 due to excess protein O-GlcNAcylation is associated with coronary microvascular disease in type 2 diabetes. Cardiovasc Res. 2020 May 1;116(6):1186-1198.

联系方式：

Email: congratulation2001@163.com