职称：

研究员

研究方向：

重大呼吸系统感染和肺损伤

研究工作：

主要在蛋白质组学技术开发、泛素化信号通路在人类疾病中的机制研究以及细胞命运调控等方向从事相关研究

科研项目：

1、2018.05-2022.04，广东省自然科学杰出青年项，2018B030306047，E2泛素结合酶 UBE2O 抑制红细胞分化的机理研究

2、2024.01-2027.12，国自然面上项目，32370752，UBE2O 介导的 CTNNA1 泛素化调控细胞黏着连接和恶性上皮肿瘤特性的机理研究

代表性学术论文：

1、Xue Shi, Xiaofei Zhang＃. Control of ATG14 solubility and autophagy by MARCHF7/MARCH7-mediated ubiquitination. Autophagy., 2023 Nov; 10.1080/15548627.2023.2278414

2、Xue Shi, Wenfeng Wu, Zhenhuan Feng, Peiyang Fan, Ruona Shi, Xiaofei Zhang＃. MARCH7-Mediated Ubiquitination Decreases the Solubility of ATG14 to Inhibit Autophagy. Cell Reports., 2023 Aug 25;42(9):113045

3、Zhenhuan Feng*, Peiyang Fang*, Hui Zheng, and Xiaofei Zhang＃. DEP2: an upgraded comprehensive analysis toolkit for quantitative proteomics data. Bioinformatics., 2023 Aug 1;39(8):btad526

4、Xue Shi, Wenfeng Wu, Zhenhuan Feng, Peiyang Fan, Ruona Shi, Xiaofei Zhang＃. MARCH7-Mediated Ubiquitination Decreases the Solubility of ATG14 to Inhibit Autophagy. Cell Reports., 2023 Aug 25;42(9):113045

5、Ruona Shi*, Zhenhuan Feng*, Xiaofei Zhang＃. Integrative Multi-omics Landscape of Non-structural Protein 3 of Severe Acute Respiratory Syndrome Coronaviruses. Genomics, Proteomics & Bioinformatics., 2021; Nov 10;S1672-0229(21)00241-2

6、Xiaofei Zhang*＃, Arne H. Smits*＃, Gabrielle B.A. van Tilburg*, Huib Ovaa, Wolfgang Huber, Michiel Vermeulen＃. Proteome-wide identification of ubiquitin interactions using UbIA-MS. Nature Protocols., 13, 530-550 (2018)

7、Xiaofei Zhang*＃, Arne H. Smits*, Gabrielle B.A. van Tilburg*, Pascal W.T.C. Jansen, Matthew M. Makowski, Huib Ovaa＃, Michiel Vermeulen＃. An Interaction Landscape of Ubiquitin Signaling. Molecular Cell., 65, 941–955 (2017)

8、Xiaofei Zhang*, Juan Zhang*, Hans van Dam, Peter ten Dijke. UBE2O negatively regulates TRAF6-mediated NF-κB activation by inhibiting TRAF6 polyubiquitination. Cell Research., 2013 Mar; 23(3):366-77

联系方式：

Email: zhang_xiaofei@gibh.ac.cn