导师介绍
| 姓名 | 牛学锋 | 性别 | 男 |
| 民族 | 汉族 | 导师层次 | 硕士生导师 |
| 职称 | 副研究员 | 导师类型 | 学术型 |
| 学历 | 博士研究生 | 学位 | 博士 |
| 行政职务 | 无 | 邮箱 | niuxuefeng@gird.cn |
| 招生方向 | 免疫学 | ||
广州市高层次人才，广州医科大学附属第一医院、广州呼吸健康研究院、呼吸疾病国家重点实验室硕士研究生导师。主要从事新发突发传染病抗体发现、流感和新冠等呼吸道病毒治疗性抗体、呼吸道疾病的免疫组库研究等。近年来主持国家自然科学基金面上项目1项，广州市科技项目1项，参与国家级、省、市级科研项目多项。近5年来发表论文30余篇，以第一作者或通讯作者发表文章12篇。
主要研究方向新发突发传染病抗体发现、流感和新冠等呼吸道病毒治疗性抗体、呼吸道疾病的免疫组库研究等。
代表性科研项目：
1、SARS-CoV康复者接种新型冠状病毒疫苗后的抗体组库分析及抗体应答机制研究，主持，国家级，2022.01-2025.12；
2、靶向A型流感病毒血凝素蛋白头部和茎部的双特异性抗体研究，主持，国重开放课题，2023.01-2025.12；
3、SARS-CoV康复者接种新型冠状病毒疫苗后的抗体组库分析及抗体应答机制研究，主持，市级，2022.04-2023.03
代表性学术论文（参考文献格式）：
1、Yan Q, Zhang Y, Hou R, Pan W, Liang H, Gao X, Deng W, Huang X, Qu L, Tang C, He P, Liu B, Wang Q, Zhao X, Lin Z, Chen Z, Li P, Han J, Xiong X, Zhao J, Li S, Niu X#, Chen L#. Deep immunoglobulin repertoire sequencing depicts a comprehensive atlas of spike-specific antibody lineages shared among COVID-19 convalescents. Emerg Microbes Infect. 2024 Dec;13(1):2290841.
2、Liang, H., Zheng, P., Wang, Q., Deng, Y., Liang, D., Yi, H., Cheng, Y., Zhao, X., Ma, J., Yang, Y., Hu, P., Zheng, P., Zhang, Y., Huang, S., Lin, X., Ke, C., Niu, X.#, Sun, B.#, Chen, L.#, 2022. Broad and durable antibody response after vaccination with inactivated SARS-CoV-2 in individuals with a history of 2003 SARS-CoV infection. Emerg Microbes Infect, 1-20.
3、Zhang, Y., Yan, Q., Luo, K., He, P., Hou, R., Zhao, X., Wang, Q., Yi, H., Liang, H., Deng, Y., Hu, F., Li, F., Liu, X., Feng, Y., Li, P., Qu, L., Chen, Z., Pan-Hammarstrom, Q., Feng, L., Niu, X.#, Chen, L.#, 2022. Analysis of B Cell Receptor Repertoires Reveals Key Signatures of the Systemic B Cell Response after SARS-CoV-2 Infection. J Virol 96, e0160021.
4、Yan, Q., He, P., Huang, X., Luo, K., Zhang, Y., Yi, H., Wang, Q., Li, F., Hou, R., Fan, X., Li, P., Liu, X., Liang, H., Deng, Y., Chen, Z., Chen, Y., Mo, X., Feng, L., Xiong, X., Li, S., Han, J., Qu, L., Niu, X.#, Chen, L.#, 2021. Germline IGHV3-53-encoded RBD-targeting neutralizing antibodies are commonly present in the antibody repertoires of COVID-19 patients. Emerg Microbes Infect 10, 1097-1111.
5、Niu, X., Li, S., Li, P., Pan, W., Wang, Q., Feng, Y., Mo, X., Yan, Q., Ye, X., Luo, J., Qu, L., Weber, D., Byrne-Steele, M.L., Wang, Z., Yu, F., Li, F., Myers, R.M., Lotze, M.T., Zhong, N., Han, J., Chen, L., 2020. Longitudinal Analysis of T and B Cell Receptor Repertoire Transcripts Reveal Dynamic Immune Response in COVID-19 Patients. Front Immunol 11, 582010.
6、Niu, X., Yan, Q., Yao, Z., Zhang, F., Qu, L., Wang, C., Wang, C., Lei, H., Chen, C., Liang, R., Luo, J., Wang, Q., Zhao, L., Zhang, Y., Luo, K., Wang, L., Wu, H., Liu, T., Li, P., Zheng, Z., Tan, Y.J., Feng, L., Zhang, Z., Han, J., Zhang, F., Chen, L., 2020. Longitudinal analysis of the antibody repertoire of a Zika virus-infected patient revealed dynamic changes in antibody response. Emerg Microbes Infect 9, 111-123.
7、Niu, X., Zhao, L., Qu, L., Yao, Z., Zhang, F., Yan, Q., Zhang, S., Liang, R., Chen, P., Luo, J., Xu, W., Lv, H., Liu, X., Lei, H., Yi, C., Li, P., Wang, Q., Wang, Y., Yu, L., Zhang, X., Bryan, L.A., Davidson, E., Doranz, J.B., Feng, L., Pan, W., Zhang, F., Chen, L., 2019. Convalescent patient-derived monoclonal antibodies targeting different epitopes of E protein confer protection against Zika virus in a neonatal mouse model. Emerg Microbes Infect 8, 749-759.
