全体研究人员 学术带头人

冉丕鑫

职务:

广州国家实验室副主任、国家呼吸医学中心副主任

职称:

教授

研究方向:

慢性气道疾病

研究工作:

主要从事慢阻肺的发病与综合防治。

科研项目:

1、慢阻肺早期药物干预效果评价及有效药物筛选,国家十三五重点研发计划,主持,2016-2021。

2、呼吸系统疾病防治研究,国家十二五科技支撑项目,主持,2012-2015。

3、慢性阻塞性肺疾病发病与早期干预研究,广东省珠江人才本土团队项目,主持,2018-2023。

4、PM2.5通过lncRNA调控NF-κB促进气道炎症的机制研究,国家自然基金,主持,2020-2023。

5、慢阻肺自然病程演进观察人群队列建立与研究,广州国家实验室项目,主持,2022-2025。

代表性学术论文:

1、Yi E, …, Ran P* .Smad3-mediated lncRNA HSALR1 enhances the non-classic signalling pathway of TGF-β1 in human bronchial fibroblasts by binding to HSP90AB1. Clin Transl Med. 2023 Jun;13(6):e1292.

2、Zhou K, …, Ran P*. Association of pectoralis muscle area on computed tomography with airflow limitation severity and respiratory outcomes in COPD: A population-based prospective cohort study. Pulmonology. 2023 Mar 10:S2531-0437(23)

3、Fu X, …, Ran P*.Wood smoke particulate matter (WSPM2.5) induces pyroptosis through both Caspase-1/IL-1β/IL-18 and ATP/P2Y-dependent mechanisms in human bronchial epithelial cells. Chemosphere. 2022 Nov;307(Pt 2):135726.

4、He F, …, Ran P*.GATA3/long noncoding RNA MHC-R regulates the immune activity of dendritic cells in chronic obstructive pulmonary disease induced by air pollution particulate matter. J Hazard Mater.2022 Sep ;15:438:129459.

5、Wang Z, …, Ran P*.SARS-CoV-2-specific CD4+ T cells are associated with long-term persistence of neutralizing antibodies. Signal Transduct Target Ther.2022 Apr 23;7(1):132.

6、Gao M, …, Ran P* .Biomass-related PM2.5 induces mitochondrial fragmentation and dysfunction in human airway epithelial cells. Environ Pollut. 2022 Jan 1;292(Pt B):118464.

7、Zheng M, …,Ran P* .lncRNA COPDA1 Promotes Airway Smooth Muscle Cell Proliferation in Chronic Obstructive Pulmonary Disease. Am J Respir Cell Mol Biol. 2019 Nov;61(5):584-596.

8、Yi E, …,Ran P*.Long noncoding RNA IL6-AS1 is highly expressed in chronic obstructive pulmonary disease and is associated with interleukin 6 by targeting miR-149-5p and early B-cell factor 1. Clin Transl Med. 2021 Jul;11(7):e479.

9、Wang Z, …, Ran P*.Exposure to SARS-CoV-2 generates T-cell memory in the absence of a detectable viral infection. Nat Commun. 2021 Mar 19;12(1):1724.

获奖及个人荣誉:

1、2015年国家科技进步奖二等奖,慢阻肺综合防治研究,第一完成人。

2、2021年国家科技进步奖创新团队奖,钟南山呼吸慢病创新团队,主要负责人。

联系方式:

Email: pxran@gzhmu.edu.cn