科研项目

1、国家自然科学基金青年项目，82201932，新冠感染者肺部病毒特异性浆细胞的表型、功能及保护机制研究，2022-01至2024-12，30万元，主持。

2、广州医科大学南山学者骨干人才项目，2024-10至2029-10，300万元，主持。

3、呼吸疾病全国重点实验室自主课题，SKLRD-Z-202324，肺部新冠病毒特异性浆细胞的表型、功能及保护机制研究，2023-01至2025-12，20万元，主持。

4、广东省基础与应用基础研究基金面上项目，体细胞缺失突变影响新冠病毒中和抗体亲和力成熟和广谱性的分子机制研究，2614050003121，2026-01至2029-01,10万元，主持。

5、中国博士后科学基金面上项目，新冠病毒感染者肺部病毒特异性浆细胞的表型、功能及保护机制研究，2022M710891，2023-01至2024-12，8万元，主持。

代表性论文

1.Yan Q*, Gao X*, Liu B*, Hou R, He P, Ma Y, Zhang Y, Zhang Y, Liu Z, Chen Q, Wang J, Huang X, Liang H, Chen X, Yao Y, Zheng H, Niu X, He J, Chen L, Zhao J, Xiong X. Antibodies utilizing VL6-57 light chains target a convergent cryptic epitope on SARS-CoV-2 spike protein and potentially drive the genesis of Omicron variants. Nat Commun. 2023 Feb 24;14(1):1058.

2.Yan Q, Zhao J. UniBind: a novel artificial intelligence-based prediction model for SARS-CoV-2 infectivity and variant evolution. Signal Transduct Target Ther. 2023 Dec 19;8(1):464.

3.Yan Q*, Zhang Y*, Hou R*, Pan W*, Liang H*, Gao X, Deng W, Huang X, Qu L, Tang C, He P, Liu B, Wang Q, Zhao X, Lin Z, Chen Z, Li P, Han J, Xiong X, Zhao J, Li S, Niu X, Chen L. Deep immunoglobulin repertoire sequencing depicts a comprehensive atlas of spike-specific antibody lineages shared among COVID-19 convalescents. Emerg Microbes Infect. 2023 Dec 4:2290841.

4.Yan Q*, Hou R*, Huang X*, Zhang Y, He P, Zhang Y, Liu B, Wang Q, Rao H, Chen X, Zhao X, Niu X, Zhao J, Xiong X, Chen L. Shared IGHV1-69-encoded neutralizing antibodies contribute to the emergence of L452R substitution in SARS-CoV-2 variants. Emerg Microbes Infect. 2022 Dec;11(1):2749-2761.

5.Yan Q*, He P*, Huang X*, Luo K, Zhang Y, Yi H, Wang Q, Li F, Hou R, Fan X, Li P, Liu X, Liang H, Deng Y, Chen Z, Chen Y, Mo X, Xiong X, Feng L, Li S, Han J, Qu L, Niu X, Chen L. Germline IGHV3-53-encoded RBD-targeting neutralizing antibodies are commonly present in the antibody repertoires of COVID-19 patients. Emerg Microbes Infect. 2021 2021 Dec;10(1):1097-1111.

6.Yan Q*, Li P*, Ye X*, Huang X* Feng B, Ji T, Chen Z, Li F, Zhang Y, Luo K, Chen F, Mo X, Wang J, Feng L, Hu F, Lei C, Qu L, Chen L. Longitudinal Peripheral Blood Transcriptional Analysis Reveals Molecular Signatures of Disease Progression in COVID-19 Patients. J Immunol. 2021 May 1;206(9):2146-2159.

7.Zhu A*, Chen Z*, Yan Q*, Jiang M*, Liu X*, Li Z*, Li N*, Tang C, Jian W, He J, Chen L, Cheng J, Chen C, Tang T, Xu Z, Hu Q, Li F, Wang Y, Sun J, Zhuang Z, Wen L, Zhuo J, Liu D, Zhang Y, Huang X, Li S, Zeng Q, Chen F, Zhou L, Liu D, Zhong C, Chen Y, Li S, Liang K, Zhong N, Zhang X, Chen J, Chen X, Xu Y, Zhong N, Zhao J, Zhao J. Robust mucosal SARS-CoV-2-specific T cells effectively combat COVID-19 and establish polyfunctional resident memory in patient lungs. Nat Immunol. 2025 Mar;26(3):459-472.

8.Wang Y*, Zhang Z*, Yang M*, Xiong X*, Yan Q*, Cao L*, Wei, P, Zhang Y, Zhang L, Lv K, Chen J, Liu X, Zhao X, Xiao J, Zhang S, Zhu A, Gan M, Zhang J, Cai R, Zhuo J, Zhang Y, Rao H, Qu B, Zhang Y, Chen L, Dai J, Cheng L, Hu Q, Chen Y, Lv H, So RTY, Peiris M, Zhao J, Liu X, Mok CKP, Wang X, Zhao J. Identification of a broad sarbecovirus neutralizing antibody targeting a conserved epitope on the receptor-binding domain. Cell Rep. 2024 Jan 3;43(1):113653.

9.He P*, Liu B*, Gao X*, Yan Q*, Pei R*, Sun J, Chen Q, Hou R, Li Z, Zhang Y, Zhao J, Sun H, Feng B, Wang Q, Yi H, Hu P, Li P, Zhang Y, Chen Z, Niu X, Zhong X, Jin L, Liu X, Qu K, Ciazynska KA, Carter AP, Briggs JAG, Chen J, Liu J, Chen X, He J, Chen L, Xiong X. SARS-CoV-2 Delta and Omicron variants evade population antibody response by mutations in a single spike epitope. Nat Microbiol. 2022 Oct;7(10):1635-1649.

10.Zhang Y*, Yan Q*, Luo K*, He P, Hou R, Zhao X, Wang Q, Yi H, Liang H, Deng Y, Hu F, Li F, Liu X, Feng Y, Li P, Qu L, Chen Z, Pan-Hammarström Q, Feng L, Niu X, Chen L. Analysis of B Cell Receptor Repertoires Reveals Key Signatures of the Systemic B Cell Response after SARS-CoV-2 Infection. J Virol. 2022 Feb 23;96(4):e0160021.