1、肺癌早筛早诊新工具及策略；

2、淋巴结微环境的分子特征、调控机制及干预方法；

3、中国人群肺癌发病高危因素及预防策略；

4、肺结节无创诊疗新方法开发；

5、肺癌术后复发预测及监测

1、2020年度，国家自然科学基金优秀青年科学基金项目，82022048，肿瘤学（肺癌转移的基础与临床研究）；

2、2023年度，国家自然科学基金面上项目，82373121，基于创新的外泌体核酸提取检测技术的早期肺癌多维精准诊断及复发监测研究；

3、 2018年度，国家自然科学基金面上项目，81871893，基于循环肿瘤DNA的早期肺癌淋巴结转移相关甲基化标志物的鉴定及无创预测工具的构建

4、广州市科技计划重点项目，201804020030，高通量测序技术检测ctDNA变异在肺癌早期诊断中的应用探索；

5、2015年度，国家自然科学基金青年项目，81501996，原发性T790M耐药突变在非小细胞肺癌EGFR基因两种敏感突变亚型之间的差异及其对靶向治疗效果的影响；

1、Accurate classification of pulmonary nodules by a combined model of clinical, imaging, and cell-free DNA methylation biomarkers: a model development and external validation study. Lancet Digit Health. 2023 Oct;5(10):e647-e656.

2、Accurate diagnosis of pulmonary nodules using a noninvasive DNA methylation test. J Clin Invest. 2021 May 17;131(10):e145973.

3、The impact of adjuvant EGFR-TKIs and 14-gene molecular assay on stage I non–small cell lung cancer with sensitive EGFR mutations. EClinicalMedicine. 2023 Sep 14:64:102205.

4、The impact of postoperative EGFR-TKIs treatment on residual GGO lesions after resection for lung cancer. Signal Transduct Target Ther. 2021 Feb 21;6(1):73.

5、Impact of Examined Lymph Node Count on Precise Staging and Long-Term Survival of Resected Non-Small-Cell Lung Cancer: A Population Study of the US SEER Database and a Chinese Multi-Institutional Registry. J Clin Oncol. 2017 Apr 10;35(11):1162-1170.

6、Development and validation of a nomogram for predicting survival in patients with resected non-small-cell lung cancer. J Clin Oncol. 2015 Mar 10;33(8):861-9.

7、Impact of lymphadenectomy extent on immunotherapy efficacy in post-resectional recurred non-small cell lung cancer: a multi-institutional retrospective cohort study.

8、GFAT1-linked TAB1 glutamylation sustains p38 MAPK activation and promotes lung cancer cell survival under glucose starvation. Cell Discov. 2022 Aug 9;8(1):77. Int J Surg. 2023 Sep 27.

9、Cancer patients in SARS-CoV-2 infection: a nationwide analysis in China. Lancet Oncol. 2020 Mar;21(3):335-337. 10. Intratumoral tertiary lymphoid structure (TLS) maturation is influenced by draining lymph nodes of lung cancer. J Immunother Cancer. 2023 Apr;11(4):e005539.