科研项目
1、2025-2027 广实科研任务专项项目“特发性肺纤维化精准诊断、发病机制及新型治疗方法的研究”(第一负责人,主持)
2、2021-2024 国家级重点研发计划 纤维化间质性肺疾病组织学诊断方法研究 (第一负责人)
3、2017-2019国家重点研发发计划项目-呼吸系统疾病专病队列研究-社区队列 呼吸疾病筛查及间质性肺疾病专病队列研究(第三负责人,课题骨干)
4、2017-2018 国家重点研发计划精准医学研究重点项目 “间质性肺病诊疗规范及应用方案的精准化研究”——常见间质性肺病基础数据平台的建立 (子课题二、子课题三参与单位负责人)
代表性成果
1、FAPI-42 PET/CT for prognostic assessment in idiopathic pulmonary fibrosis: a prospective head-to-head comparison with [18F]FDG PET/CT
2、Unilateral Lung Volume Analysis Using Micro-CT for Enhanced Assessment of Pulmonary Fibrosis in Preclinical Models.
3、nnU-Net-based high-esolution CT featues quantification for interstitial lung diseases.
4、Autologous P63+ lung progenitor cell transplantation in idiopathic pulmonary fibrosis a phase 1 clinical trial
5、Delayed Viral Clearance Accompanied by Early Impaired Humoral and Virus-Specific T-Cell Response in Patients with Coronavirus Disease 2019 and Interstitial Lung Disease
6、Comprehensive Analysis of Fibroblast Activation Protein (FAP) Expression in Interstitial Lung Diseases (ILDs) .
7、Characterizing the lavage and serum cytokine profiles of interstitial pneumonia with autoimmune features and their implications for progressive fibrosis.
8、Inhibition of miR-199a-5p rejuvenates aged mesenchymal stem cells derived from patients with idiopathic pulmonary fibrosis and improves their therapeutic efficacy in experimental pulmonary fibrosis.
9、Deleterious role of Th9 cells in pulmonary fibrosis.
10、The Role of Follow-up Evaluation in the Diagnostic Algorithm of Idiopathic Interstitial Pneumonia: A Retrospective Study. 6.Ultra-low dose rituximab as add-on theerapy in anti-MDA5-positive patients with polymyositis/dermatomyositis associated ILD.
获奖及个人荣誉
1、中华医学科技奖一等奖 呼吸支持技术的临床应用研究 国家级
2、教育部科技进步二等奖 无创正压通气临床应用的系列研究 国家级
3、国家科学技术进步奖 呼吸衰竭的发病机理与治疗研究 国家级
4、广州市科学技术奖 无创正压通气临床应用的系列研究 省部级