职称：

教授

研究方向：

肺癌

研究工作：

长期研究自噬及自噬介导的蛋白运输在肺癌、COPD和肺纤维化中的作用

代表性学术论文：

1、Wei Y, Pattingre S, Sinha S, Bassik M, Levine B*. JNK1-mediated phosphorylation of Bcl-2 regulates starvation-induced autophagy. Mol Cell. 2008, Jun 20;30(6):678-88.

2、Wei Y, Sinha S, Levine B*. Dual role of JNK1-mediated phosphorylation of Bcl-2 in autophagy and apoptosis regulation. Autophagy. 2008, Oct;4(7):949-51

3、Wang RC, Wei Y, An Z, Zou Z, Xiao G, Bhagat G, White M, Reichelt J, Levine B*. Akt-mediated regulation of autophagy and tumorigenesis through Beclin 1 phosphorylation. Science. 2012, Nov 16;338(6109):956-9.

4、He C, Wei Y, Sun K, Li B, Dong X, Zou Z, Liu Y, Kinch L, Khan S, Sinha S, Xavier R, Grishin N, Xiao G, Eskelinen E, Scherer P, Whistler J and Levine B*. Beclin 2 Functions in Autophagy, Degradation of G Protein-Coupled Receptors, and Metabolism. Cell. 2013, 154(5):1085-99

5、Wei Y, Zou Z , Becker N, Anderson M, Sumpter R, Borczuk A, Xiao G, Peyton M, Minna J, Bhagat G, and Levine B*. EGFR-Mediated Phosphorylation of Beclin 1 in Autophagy Suppression, Tumor Progression and Tumor Chemoresistance. Cell. 2013, 154(6):1269-84.

6、Wei Y, An Z, Zou Z, Sumpter R, Su M, Zang X, Sinha S, Gaestel M, Levine B*. The stress-responsive kinases MAPKAPK2/MAPKAPK3 activate starvation-induced autophagy through Beclin 1 phosphorylation. Elife. 2015, Feb 18;4. doi:10.7554/eLife.05289.

7、Pedro JM#, Wei Y#, Sica V, Maiuri MC, Zou Z, Kroemer G, Levine B*. BAX and BAK1 are dispensable for ABT-737-induced dissociation of the BCL2-BECN1 complex and autophagy. Autophagy, 2015, 11(3):452-9

8、Wei Y, Chiang WC, Sumpter R Jr, Mishra P, Levine B*. Prohibitin 2 Is an Inner Mitochondrial Membrane Mitophagy Receptor. Cell. 2017, 168(1-2):224-238

9、Chiang W#, Wei Y#, Zhou A, Kuo Y, Zou Z, Yehl J, Ranaghan M, Skepner A, Bittker JA, Zhang X, Posner BA, Perez JA, and Levine B. High Throughput Screens to Identify Autophagy Inducers that Function by Disrupting Beclin 1/Bcl-2 Binding. ACS Chemical Biology. 2018 June 21 doi: 10.1021/acschembio.8b00421

10、BC Levine, RC Wang, Y Wei Beclin 1 phosphorylation - US Patent 9,671,412, 2017

联系方式：

Email: weiyongjie@gzhmu.edu.cn