深耕于RNA m6A修饰的基础及转化研究，鉴定出一类新型m6A “阅读器”，发现RNA m6A修饰受组蛋白修饰调控的新机制，并对m6A修饰在肿瘤中的功能及靶向展开了深入的探索。

1、中国科学技术部, 国家重点研发计划“干细胞及转化研究”重点专项子课题, 2020YFA0112403, 中胚层特异干细胞的体外获得及调控（“中胚层特异干细胞的建立与调控”项目子课题）, 2020-10 至 2024-12, 738万元, 在研, 主持

2、国家自然科学基金委员会，面上项目，82270168，RNA m6A甲基化阅读器IGF2BP2调控谷氨酰胺代谢促进急性髓系白血病的机制研究，2023-01至2026-12，52万元，在研，主持

3、广东省科学技术厅，广东省创新创业团队，ZJTD22-001，肺器官的体外谱系重建及其应用，2023-01至2027-12，1000万元，在研，第一核心成员

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3、Huang H#, Weng H#, Zhou K#, Wu T#, Zhao BS#, Sun M, Chen Z, Deng X, Xiao G, Auer F, Klemm L, Wu H, Zuo Z, Qin X, Dong Y, Zhou Y, Qin H, Tao S, Du J, Liu J, Lu Z, Yin H, Mesquita A, Yuan CL, Hu Y-C, Sun W, Su R, Dong L, Shen C, Li C, Qing Y, Jiang X, Wu X, Sun M, Guan J-L, Qu L, Wei M, Muschen M, Huang G*, He C*, Yang J*, and Chen J*. Histone H3 trimethylation at lysine 36 guides m6A RNA modification co-transcriptionally. Nature 2019, 567:414-419.

4、Li Z#, Weng H#, Su R#, Weng X#, Zuo Z#, Li C, Huang H, Nachtergaele S, Dong L, Hu C, Qin X, Tang L, Wang Y, Hong GM, Huang H, Wang X, Chen P, Gurbuxani S, Arnovitz S, Li Y, Li S, Strong J, Neilly MB, Larson RA, Jiang X, Zhang P, Jin J, He C*, Chen J*. FTO Plays an Oncogenic Role in Acute Myeloid Leukemia as a N6-Methyladenosine RNA Demethylase. Cancer Cell 2017, 31:127-141.

5、Huang H#, Weng H#, Sun W#, Qin X#, Shi H#, Wu H, Zhao BS, Mesquita A, Liu C, Yuan CL, Hu YC, Hüttelmaier S, Skibbe J, Su R, Dong L, Sun M, Li C, Nachtergaele S, Wang Y, Hu C, Ferchen K, Greis KD, Jiang X, Wei M, Qu L, Guan JL, He C*, Yang J*, Chen J*. Recognition of RNA N6-methyadenosine by IGF2BP proteins Enhances mRNA Stability. Nature Cell Biology 2018, 20:285-295.