冯立强
职务:
中国科学院广州生物医药与健康研究院感染与免疫研究中心主任
职称:
研究员
研究方向:
重大呼吸系统感染和肺损伤
研究工作:
主要从事新发突发传染病疫苗研究,现阶段主要集中于新冠、蚊媒黄病毒疫苗以及新型疫苗载体研发。
科研项目:
1、运用环状RNA携载EDIII及NS1抗原探索安全强效的寨卡病毒疫苗 32370998 国家自然科学基金面上项目 2024-2027 50万元(主持)
2、新型冠状病毒诱导黏膜免疫的机制及预防治疗策略研究 82061138006 国家自然科学基金国际(地区)合作与交流项目 2021-2023 300万元(主持)
3、新型流感病毒载体艾滋病疫苗诱导黏膜免疫反应的作用及机制研究 31470892 国家自然科学基金面上项目 2015-2018 85万元(主持)
代表性学术论文:
1、Booster vaccination is required to elicit and maintain COVID-19 vaccine-induced immunity in SIV-infected macaques. Emerging Microbes & Infections.2023,12(1):e2136538.(Article,IF=13.2)
2、Monoclonal Antibodies against Zika Virus NS1 Protein Confer Protection via Fc gamma Receptor-Dependent and -Independent Pathways. mBio. 2021,12(1):e03179-20.(Article,IF=6.4)
3、A Live-Attenuated Zika Virus Vaccine with High Production Capacity Confers Effective Protection in Neonatal Mice. Journal of Virology. 2021,95(14):e0038321.(Article,IF=5.4)
4、Mucosal Priming with a Recombinant Influenza A Virus-Vectored Vaccine Elicits T-Cell and Antibody Responses to HIV-1 in Mice. Journal of Virology. 2021,95(12):e00059-21.(Article,IF=5.4)
5、An adenovirus-vectored COVID-19 vaccine confers protection from SARS-COV-2 challenge in rhesus macaques. Nature Communications.2020,11(1):4207. (Article,IF=16.6)
6、Molecular typing and genomic characteristic of human adenoviruses in Datong, Northern China. Journal of Medical Virology. 2020,92(12):3111-3118. (Article,IF=12.7)
7、Human Desmoglein-2 and Human CD46 Mediate Human Adenovirus Type 55 Infection, but Human Desmoglein-2 Plays the Major Roles. Journal of Virology. 2020,94(17):e00747-20.(Article,IF=5.4)
8、An adenovirus serotype 2-vectored ebolavirus vaccine generates robust antibody and cell-mediated immune responses in mice and rhesus macaques. Emerging Microbes & Infections.2018,7(1):101.(Article,IF=13.2)
9、Incorporation of NS1 and prM/M are important to confer effective protection of adenovirus-vectored Zika virus vaccine carrying E protein. npj Vaccines.2018,3:29.(Article,IF=9.2)
获奖及个人荣誉:
1、新冠肺炎诊断试剂科技攻关技术平台的建立及应用 北京市科学技术进步奖(二等奖) 2021
联系方式:
Email: feng_liqiang@gibh.ac.cn