广州医科大学附属市八医院传染病研究所副所长

职称：

研究员

研究方向：

重大呼吸系统感染和肺损伤

研究工作：

1、专注人干扰素体内抗病毒免疫机制。构建基于干扰素修饰小鼠的30种病毒性病毒感染小鼠模型，包括I型干扰素通路缺陷小鼠、II型干扰素通路缺陷小鼠、I型+II型干扰素缺陷小鼠、I+II+III型干扰素全部敲除小鼠、I型干扰素受体人源化小鼠和III型干扰素受体人源化小鼠。探索人干扰素抗病毒治疗时机，研究对象为，SARS-CoV-2、流感、呼吸道合胞病毒、偏肺病毒、鼻病毒等呼吸道病毒和HIV、肝炎病毒、虫媒病毒、肠道病毒等多种病毒模型。

2.、面向传染病临床救治的相关研究。

科研项目：

1、新冠非重症感染者上呼吸道病毒核酸持续和再现的免疫学机制与对策。项目类型：国家自然科学基金（重大研究计划） 项目批准号：92269108，实施时间：2023.1-2025.12 资助金额：70万 项目负责人

2、华南地区主要流行人类病毒模式小鼠资源库的建立及评估应用 项目类型：广东省重点领域研发计划 项目批准号：2022B1111020002，实施时间：2022.1-2024.12 资助金额：2360万 项目主要负责人

3、奥密克戎变异规律分析与防控研究。 项目类型：科技部国家重点研发计划 项目批准号：2023YFC3041500，实施时间：2023.04-2024.03 资助金额：50万 子课题1任务3负责人

代表性学术论文：

1、Yaping Wang, Liliangzi Guo, Jingrong Shi, Jingyun Li, Yanling Wen, Guoming Gu, Jianping Cui, Chengqian Feng, Mengling Jiang, Qinghong Fan, Jingyan Tang, Sisi Chen, Jun Zhang, Xiaowen Zheng, Meifang Pan, Xinnian Li, Yanxia Sun, Zheng Zhang, Xian Li, Fengyu Hu, Liguo Zhang, Xiaoping Tang*, Feng Li*. Interferon stimulated immune profile changes in a humanized mouse model of HBV infection. Nature Communications. 2023 Nov 15;14(1):7393.

2、Lu Li, Jingyan Tang, Zhiwei Xie, Qingxin Gan, Guofang Tang, Zhongwei Hu, Huimin Zeng, Jingrong Shi, Jiaojiao Li, Yan Li, Changwen Ke, Min Kang, Dan Liang, Huan Lu, Yuwei Tong, Xilong Deng, Jinxin Liu, Hongzhou Lu, Fuxiang Wang, Fengyu Hu, Feng Li*, Nanshan Zhong*, Xiaoping Tang*. Characteristics of SARS-CoV-2 Delta variant-infected individuals with intermittently positive retest viral RNA after discharge. National Science Review 2022 Jul 26; 9(10):nwac141.

3、Qinghong Fan, Jingrong Shi, Yanhong Yang, Guofang Tang, Mengling Jiang, Jiaojiao Li, Jingyan Tang, Lu Li, Xueliang Wen, Lieguang Zhang, Xizi Deng, Yaping Wang, Yun Lan, Liya Li, Ping Peng, Yuwei Tong, Huan Lu, Lili Yan, Ying Liu, Shuijiang Cai, Yueping Li, Xiaoneng Mo, Meiyu Li, Xilong Deng, Zhongwei Hu, Haisheng Yu, Fengyu Hu, Jinxin Liu * , Xiaoping Tang *, Feng Li *. Clinical characteristics and immune profile alterations in vaccinated individuals with breakthrough Delta SARS-CoV-2 infections. Nature Communications. 2022 Jul 9;13(1):3979

4、Yaping Wang, Ruchong Chen, Fengyu Hu,, Yun Lan, Zhaowei Yang, Chen Zhan, Jingrong Shi, Xizi Deng, Mei Jiang, Shuxin Zhong, Baolin Liao, Kai Deng, Jingyan Tang, Liliangzi Guo, Mengling Jiang, Qinghong Fan, Meiyu Li, Jinxin Liu, Yaling Shi, Xilong Deng, Xincai Xiao, Min Kang, Yan Li, Weijie Guan, Yimin Li, Shiyue Li, Feng Li*, Nanshan Zhong*, Xiaoping Tang*. Transmission, viral kinetics and clinical characteristics of the emergent SARS-CoV-2 Delta VOC in Guangzhou, China. EClinicalMedicine 2021 Oct;40:101129. doi: 10.1016/j.eclinm.2021.101129.

5、Chengqian Feng, Jingrong Shi, Qinghong Fan, Yaping Wang, Huang Huang, Fengjuan Chen, Guofang Tang, Youxia Li, Pingchao Li, Jiaojiao Li, Jianping Cui, Liliangzi Guo, Sisi Chen, Mengling Jiang, Liqiang Feng, Ling Chen, Chunliang Lei, Changwen Ke, Xilong Deng*, Fengyu Hu*, Xiaoping Tang*, Feng Li*. Protective humoral and cellular responses against SARS-CoV-2 persist up to 1 year after recovery. Nature Communications. 2021 Aug 17. 12(1). 4984

6、Fengyu Hu, Fengjuan Chen, Zhihua Ou, Qinghong Fan, Xinghua Tan, Yaping Wang, Yuejun Pan, Bixia Ke, Linghua Li, Yujuan Guan, Xiaoneng Mo, Jian Wang, Jinlin Wang, Chun Luo, Xueliang Wen, Min Li, Peidi Ren, Changwen Ke, Junhua Li, Chunliang Lei*, Xiaoping Tang*, Feng Li* (2020) Compromised specific humoral immune response against SARS-CoV-2 receptor-binding domain is related to the viral persistence and periodic shedding in the gastrointestinal tract. Cellular & Molecular Immunology 2020 Nov;17(11):1119-1125

7、Weilie Chen, Yun Lan, Xiaozhen Yuan, Xilong Deng, Yueping Li, Xiaoli Cai, Liya Li, Ruiying He, Yizhou Tan, Xizi Deng, Ming Gao, Guofang Tang, Lingzhai Zhao, Jinlin Wang, Qinghong Fan, Chunyan Wen, Yuwei Tong, Yangbo Tang, Fengyu Hu*, Feng Li *&Xiaoping Tang* (2020) Detectable 2019-nCoV viral RNA in blood is a strong indicator for the further clinical severity. Emerging Microbes & Infections. 2020 Feb 26;9(1):469-473.

联系方式：

Email: gz8h_lifeng@126.com