全体研究人员 学术带头人

门冬

职称:

研究员

研究方向:

重大呼吸系统感染和肺损伤

研究工作:

1、基于合成生物学、纳米生物学的新型疾病检测技术

2、基于微流控芯片与新型传感器件的生物传感系统

3、基于人工智能的生物大分子理性设计

科研项目:

1、国家自然科学基金,面上项目,三特异性Janus纳米颗粒的胞内可控制备与多效应肿瘤免疫治疗,69.6万元,2018.01-2021.12,主持;

2、国家自然科学基金,青年基金,模块化设计多功能蛋白纳米线及超灵敏生物传感应用,23万元,2013.01-2015.12,主持;

3、国家重点研发计划(新冠应急攻关),新型冠状病毒肺炎抗原检测系统的研发,1万元,2020.02-2020.04,课题负责人;

4、国家重点研发计划(新冠应急攻关),新冠肺炎无症状感染和复阳的机制与对策研究,50万元,2020.07-2020.12,课题负责人;

5、国家重点研发计划(合成生物学专项),面向生物过程检测的合成生物传感元器件设计与创建,177万,2020.01-2021.12,骨干;

代表性学术论文:

1、Men D, Guo YC, Zhang ZP, Wei HP, Zhou YF, Cui ZQ, Liang XS, Li K, Leng Y, You XY, Zhang XE. Seeding-induced self-assembling protein nanowires dramatically increase the sensitivity of immunoassays. Nano Lett. 2009 Jun;9(6):2246-50.

2、Men D, Zhang TT, Hou LW, Zhou J, Zhang ZP, Shi YY, Zhang JL, Cui ZQ, Deng JY, Wang DB, Zhang XE*. Self-Assembly of Ferritin Nanoparticles into an Enzyme Nanocomposite with Tunable Size for Ultrasensitive Immunoassay. ACS Nano. 2015 Nov 24;9(11):10852-60.

3、Wei CH, Zhou J, Liu TG, Zhao WQ, Zhang XE*, Men D*. Self-Assembled Enzymatic Nanowires with a “Dry and Wet” Interface Improve the Catalytic Performance of Januvia Transaminase in Organic Solvents[J]. ACS Catalysis, 2021, 12: 372-382.

4、Li Y, Zhou J, Song J, Liang X, Zhang Z, Men D*, Wang D, Zhang XE*. Chemical nature of electrochemical activation of carbon electrodes. Biosens Bioelectron. 2019 Nov 1;144:111534.

5、Jiang HW, Li Y, Zhang HN, Wang W, Yang X, Qi H, Li H, Men D*, Zhou J*, Tao SC*. SARS-CoV-2 proteome microarray for global profiling of COVID-19 specific IgG and IgM responses. Nat Commun. 2020 Jul 14;11(1):3581.

6、Cao S#, Zhang Q#, Song L#, Xiao M#, Chen Y#, Wang D, Li M, Hu J, Lin L, Zheng Y, Zhou K, Ye S, Zhou J, Zhou YN, Cui J, Wang J, Sun J, Tao J, Chen Z, Chen R, Zhou P, Shi Z, Wei S, Zhao L, Wang H*, Tong X*, Li X*, Men D*, Hou B*, Zhang XE*. Dysregulation of Innate and Adaptive Immune Responses in Asymptomatic SARS-CoV-2 Infection with Delayed Viral Clearance. Int J Biol Sci. 2022 Jul 11;18(12):4648-4657.

7、Chen X#, Zhou J#, Chen C#, Hou B, Ali A, Li F, Hua Z, Wu Y, Yang Q, Chen M, Zhang R, Huang Q*, Ding J*, Zhang XE*, Men D*. Consecutive Monitoring of Interleukin-6 Is Needed for COVID-19 Patients. Virol Sin. 2021 Oct;36(5):1093-1096.

8、Men D, Zhang ZP, Guo YC, Zhu DH, Bi LJ, Deng JY, Cui ZQ, Wei HP, Zhang XE. An auto-biotinylated bifunctional protein nanowire for ultra-sensitive molecular biosensing. Biosens Bioelectron. 2010 Dec 15;26(4):1137-41.

获奖及个人荣誉:

1、中科院“国科大”杯创新创业大赛二等奖(2019)

2、中科院青促会优秀会员(2018)

3、中科院“率先杯”未来技术创新大赛优胜奖(2018)

4、中科院青年创新促进会(2014)

联系方式:

Email: men_dong@gzlab.ac.cn