职称：

研究员

研究方向：

间质性肺病和肺血管病

研究工作：

1、转分化在血管再生及纤维化中的机制和应用

2、干细胞-血管内皮细胞分化的机制和应用

3、核酸药物在肺部疾病中的应用

科研项目：

1、国家自然科学基金委员会面上项目（82170512）: 蛋白去亚硝基化机制在转分化和血管再生中的研究（主持）

2、美国国立卫生院NHLBI RO1: Reversal of heart failure: role of vascular recovery（参与）

3、美国Kostas基金会: Modulation of mesenchymal-to-endothelial transition by novel mmRNA based method to improve peripheral artery disease outcomes（主持）

4、美国Kostas基金会：mmRNA based transdifferentiation of fibroblasts to inducible vascular endothelial cells in myocardial infarction（主持）

5、美国心脏病协会AHA Career Development Grant：Transdifferentiation of fibroblasts to endothelial cells contributes to angiogenesis- Role of TLR3 signaling（主持）

代表性学术论文：

1、Liu Q, Wang Y, Zhang T, Fang J, Meng S. Circular RNAs in vascular diseases. Frontiers in Cardiovascular Medicine, 2023.

2、Lv J, Meng S, Gu Q, Zheng R, Gao X, Kim JD, Chen M, Xia B, Zuo Y, Zhu S, Zhao D, Li Y, Wang G, Wang X, Meng Q, Cao Q, Cooke JP, Fang L, Chen K and Zhang L. Epigenetic landscape reveals MECOM as an endothelial lineage regulator. Nat Commun. 2023;14(1):2390

3、Meng S, Lv J, Chanda P, Owusu I, Chen K, Cooke J. A Reservoir of Fibroblasts Promotes Recovery from Limb Ischemia. Circulation. 2020.

4、Cooke J, Meng S. Vascular regeneration in peripheral artery disease. Arteriosclerosis, Thrombosis, and Vascular Biology. 2020.

5、Chanda P, Meng S, Lee J, Leung H, Chen K, Cooke JP. Nuclear S-nitrosylation defines an optimal zone for inducing pluripotency. Circulation. 2019.

6、Meng S, Chanda P, Thandavarayan RA, Cooke JP. Transflammation: How Innate Immune Activation and Free Radicals Drive Nuclear Reprogramming. Antioxidants & Redox Signaling. 2018;29:205-218

7、Meng S, Gu Q, Yang X, Lv J, Owusu I, Matrone G, Chen KF, Cooke J, Fang L. TBX20 regulates angiogenesis through the PROK2-PROK1R pathway. Circulation. 2018;138:913-928.

8、Meng S, Chanda P, Thandavarayan RA, Cooke JP. Transflammation: Innate immune signaling in nuclear reprogramming. Advanced drug delivery reviews. 2017;120:133-141

9、Matrone G, Meng S, Gu Q, Lv J, Fang L, Chen K, Cooke JP. Lmo2 (lim-domain-only 2) modulates sphk1 (sphingosine kinase) and promotes endothelial cell migration. Arteriosclerosis, Thrombosis, and Vascular Biology. 2017;37:1860-1868

联系方式：

Email: meng_shu@gzlab.ac.cn