呼吸介入领域方面：OCT技术在小气道检测、气道病变动物模型的建立及干预、气道介入新设备的研发及转化、气道介入技术临床多中心研究。其中OCT技术在小气道检测达到了国际领先水平。
再生医学：气道干细胞的功能研究、干细胞在气道疾病应用的基础及临床多中心研究。

主持科技部国家重点研发计划、国家自然科学基金、卫计委重大专项课题、省市各级科研项目等。主持开展多项呼吸介入领域的前瞻性多中心临床研究和前沿基础研究。

1、Lisi Luo#, Junfeng Huang#, Difei Chen#, Huijie Yang#, Yuling Deng, Yushan He, Jinsheng Lin, Ruiyue Zhao, Xinlu Wang, Zhuquan Su, Huanjie Chen, Minting Wu, Yingying Gu, Zhucheng Chen, Ning Ma*, Shiyue Li*. Airway basal stem cell-derived extracellular vesicles drive ECM remodeling and suppress fibroblasts activation via the miR-30a-5p/FAP axis in benign tracheal stenosis.J Adv Res. 2026 May:83:759-773. doi: 10.1016/j.jare.2025.08.014. IF=17.1

2、Di-Fei Chen#, Zhu-Quan Su#, Yu-Long Luo#, Zi-Qing Zhou, Zu-Yuan Guo, Li-Hong Yao, Jing-Wei Liu, Yu Chen, Kian Fan Chung, Chang-Hao Zhong, Xiao-Bo Chen, Chun-Li Tang, Shi-Yue Li*. Establishment of a novel severe asthma canine model: Feasible research platform of respiratory intervention therapies. Allergy. 2025 May;80(5):1513-1517. doi: 10.1111/all.16207. IF=12

3、Junfeng Huang#, Difei Chen, Zikai Lin, Huijie Yang, Shiyue Li*.Sowing Tailored Seeds: Gene-edited Basal Cells for Precision Regulation of Airway Phenotypes.Am J Respir Crit Care Med.2025 Feb 25;211(5):883-884. doi: 10.1164/rccm.202412-2401LE. IF=19.4

4、Ming Liu #, Guihuan Qiu #, Wenhui Guan #, Xiaohong Xie, Xinqing Lin, Zhanhong Xie, Jiexia Zhang, Yinyin Qin, Haijian Du, Xin Chen, Yu Deng, Shiyue Li*, Nanshan Zhong*, Chengzhi Zhou*.Induction chemotherapy followed by camrelizumab plus apatinib and chemotherapy as first-line treatment for extensive-stage small-cell lung cancer: a multicenter, single-arm trial.Signal Transduct Target Ther. 2025 Feb 18;10(1):65.PMID: 39962074 IF=52.7

5、Junfeng Huang #, Zikai Lin #, Jinsheng Lin #, Shuojia Xie #, Shixin Xia, Gengjia Chen, Ziwen Zheng, Zhe Xu, Fangcheng Liu, Hongkai Wu*, Shiyue Li*. Causal role of lipid metabolism in pulmonary alveolar proteinosis: an observational and mendelian randomisation study. Thorax. 2024 Jan 18;79(2):135-143. doi: 10.1136/thorax-2023-220789. PMID: 38124156. IF=10

作为核心成员获得获得2020年“全国创新争先奖” 广州医科大学新冠肺炎疫情防控研究南山团队、2022年第三届广东医学科技奖二等奖，2021年广东省科技进步特等奖以及2020年广东医师奖。