题　目：

Coronavirus Fusion Triggering Mechanism Revealed by Electron Microscopy

主讲人：

熊晓梨(MRC Laboratory of Molecular Biology)



主持人：

陈凌 教授

时　间：

2019年3月11日（星期一）上午 10:30 – 12:00

地　点：

广州医科大学越秀校区16号楼五楼东侧大会议室

内容介绍：

In this talk, Dr.Xiong will present a cryo-EM structure of the SARS-CoV S glycoprotein in complex with a neutralising antibody isolated from a SARS survivor, this structure reveals an un-expected spike protein conformation that represents a fusogenic intermediate state. This intermediate state is shown to be induced by antibody binding to the S receptor binding domain. Inspired by this structure, we confirmed, by a series of biochemical experiments, that binding of the receptor rather than pH change or proteolytic activation serves the fusion trigger for SARS-CoV and possibly other coronaviruses. This result also suggests antibodies target the S receptor binding region may be advantageous due to its potential of inducing premature fusion triggering.

欢迎对以上内容感兴趣的科研人员、临床医生、学生到场参加交流！

广州医科大学附属第一医院

广州呼吸健康研究院

呼吸疾病国家重点实验室

国家呼吸系统疾病临床医学研究中心

2019年3月8日