Cough is a common complaint in respiratory and allergic specialties, and many pulmonary and extrapulmonary diseases are manifested as chronic cough (adult cough> 8 weeks and pediatric cough> 4 weeks). Increased cough sensitivity is an important clinical and pathophysiological feature of the chronic cough in adults, and the cough can be triggered by low levels of mechanical, chemical substance and temperature stimulation. The heavy medical burden caused by persistent chronic cough has attracted much attention to high cough sensitivity as an independent cough trigger.

In recent years, much progress has been made in the studying of the pathogenesis and regulation of high cough sensitivity. Under this context, the international authoritative experts in the field of cough co-prepared the “Cough hypersensitivity and chronic cough review”, which was published in the international authoritative magazine Nature Reviews Disease Primers on June 30 this year. The experts involved in the writing of the paper came from countries such as the UK, the US, China, Australia, and South Korea, including Kian Fan Chung, Lorcan McGarvey, Woo-Jung Song, Anne Chang, Brendan Canning, Suringder Burring, Jacky Smith, and Stuart Mazzone. Professor Lai Kefang with SKLRD participated in the writing of the article.

The review introduces the epidemiology of chronic cough around the four main factors, cough trigger, patients, clinical and environment, expounds its pathogenesis from peripheral and central nervous sensitization, and reviews the evaluation means, etiology distribution, diagnosis and treatment methods of chronic cough. Finally, it points out the existing problems and the future development direction of chronic cough research, the internal type and individualized treatment of cough with high sensitivity, and the research and development of new target drugs, etc.

Original review：https://mp.weixinbridge.com/mp/wapredirect?url=https%3A%2F%2Fwww.nature.com%2Farticles%2Fs41572-022-00370-w