Recently, the team led by Professor Zhang Xiaowen has published an article titled “Temperature regulates Rab3a and mast cell-derived exosomal FcεRI to inhibit mast cell activation” in the internationally renowned medical journal Allergy (IF: 14.710).

Asthma is a common chronic respiratory disease. Asthma patients often show symptoms such as wheezing, cough, and chest tightness . The research team has discovered that thermal stimulation can promote the secretion of exosomes by mast cells, and that these vesicles can inhibit the activation of mast cells, thereby relieving the asthma symptoms. Experimental results showed that exosomes secreted by mast cells have a stronger inhibition effect on the activation of mast cells.

Figure 1. Mast cell-derived exosomes upregulate exosomal FcεRI expression and inhibit mast cell activation in vitro under thermal stimulation

The team injected cellular exosomes produced under 41℃ into the mice in a mouse model of experimental asthma and found that it significantly relieved asthma symptoms and lowered the serum IgE levels and the number of inflammatory cells. Moreover, the Rab3a gene is one of the key genes associated with vesicle secretion, and high temperatures can promote the expression of this gene, thus promoting the secretion of cellular exosomes and FcεRI expression. Rab3a attenuates the activating effects of mast cells through a temperature-dependent regulation of RBL-2H3 cell-derived exosomes.

Figure 2. Rab3a attenuated the activation of mast cells through a temperature-dependent regulation of RBL-2H3 cell-derived exosomes

This study has revealed the exosome-mediated inhibition of mast cells under thermal stimulation, providing a new idea for the development of new therapies for asthma. In the future, the research team will further explore the potential applications of mast cell exosomes prepared under high temperatures in the treatment of chronic respiratory diseases.

Original link：https://onlinelibrary.wiley.com/doi/10.1111/all.15744